ArticleJournal of affective disorders2019
Inflammation as a unique marker of suicide ideation distinct from depression syndrome among U.S. adults.
Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Peripheral blood cellular immunophenotype in suicidal ideation, suicide attempt, and suicide: a systematic review and meta-analysis.Molecular psychiatry · 2024Pooled it
- Potential Inflammatory Biomarkers for Major Depressive Disorder Related to Suicidal Behaviors: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Longitudinal Analysis of Associations Between Dietary Patterns and Incident Suicidal Ideation.Nutrients · 2026Article
- Curcumin alleviates depression-aggravated psoriasis by targeting MMP9-regulated apoptotic pathways.iScience · 2026Article
- Low-grade inflammatory parameters may be associated with recent suicide attempts - a naturalistic study among psychiatric inpatients with depressive disorders.Frontiers in psychiatry · 2026Article
- Pro-inflammatory cytokines level in depressed patients with suicidal behaviour: a systematic review and meta-analysis.Annals of general psychiatry · 2025Article
- Ultraprocessed foods consumption, inflammatory index levels, and risk of suicide attempt: findings from a prospective cohort study.The American journal of clinical nutrition · 2025Article
- Inflammatory markers and suicidal behavior: A comprehensive review of emerging evidence.Annals of general psychiatry · 2025Review
- Changes in the distribution of elements in the liver and various brain regions in suicides from southeastern Poland.Scientific reports · 2025Article
- Evening Chronotype and Suicide: Exploring Neuroinflammation and Psychopathological Dimensions as Possible Bridging Factors-A Narrative Review.Brain sciences · 2023Review
- Strong associations of telomere length and mitochondrial copy number with suicidality and abuse history in adolescent depressed individuals.Molecular psychiatry · 2023Article
- Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio in depressed patients with suicidal behavior: A systematic review.European psychiatry : the journal of the Association of European Psychiatrists · 2023Review
- Inflammation Assessed by Latent Profiling is Associated with Stress and Suicidality but not Depression: Findings from the RADAR Cohort Study.Annals of LGBTQ public and population health · 2023Article
- Understanding Suicide over the Life Course Using Data Science Tools within a Triangulation Framework.Journal of psychiatry and brain science · 2023Article
- Ketamine study: Protocol for naturalistic prospective multicenter study on subcutaneous ketamine infusion in depressed patients with active suicidal ideation.Frontiers in psychiatry · 2023Article
- Leveraging a genetically-informative study design to explore depression as a risk factor for type 2 diabetes: Rationale and participant characteristics of the Mood and Immune Regulation in Twins Study.Frontiers in clinical diabetes and healthcare · 2023Article
- Article
- Integrating biobehavioral information to predict mood disorder suicide risk.Brain, behavior, & immunity - health · 2022Review
- Suicide Biomarkers to Predict Risk, Classify Diagnostic Subtypes, and Identify Novel Therapeutic Targets: 5 Years of Promising Research.The international journal of neuropsychopharmacology · 2022Review
- The Brain-Skin Axis in Psoriasis-Psychological, Psychiatric, Hormonal, and Dermatological Aspects.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundRecent evidence suggests that pro-inflammatory states may be independently associated with the risk of suicidality, above and beyond depression. This study assesses whether four indicators of inflammation, circulating levels of C-reactive protein (CRP), white blood cell (WBC) count and immunoglobulin E (IgE), and dietary inflammatory potential, measured using the Dietary Inflammatory Index® (DII), distinguish suicidal ideation (SI) from major depression (MD).
methodsData come from multiple cycles of the US National Health and Nutrition Examination Survey (N
resultsNone of the inflammatory indicators were able to distinguish SI status among MD cases. DII was associated with SI among individuals without MD. CRP, DII, and WBC were associated with MD. No associations were found for IgE. LIMITATIONS: Cross-section data prevent drawing causal conclusions. Underreporting of MD and suicidal ideation and measurement of habitual diet using 24 h dietary recalls are also weaknesses.
conclusionDietary inflammatory potential was associated with suicide ideation among US adults with and without depression. Diet may play a role in suicide ideation and more empirical evidence is needed to determine whether nutritional protocols could aid in the treatment of suicidal behaviors. Findings did not support inflammatory factors having a relationship with suicide ideation distinct from depression.
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Registered trials
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