Evidence map›Paper›PMID 30699498›Full record

ArticleCancer research and treatment2019

The Prognostic Value of Albumin-to-Alkaline Phosphatase Ratio before Radical Radiotherapy in Patients with Non-metastatic Nasopharyngeal Carcinoma: A Propensity Score Matching Analysis.

Jae Sik Kim, Bhumsuk Keam, Dae Seog Heo, Doo Hee Han, Chae-Seo Rhee, Ji-Hoon Kim, Kyeong Cheon Jung, Hong-Gyun Wu

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In one paragraph

Article in Cancer research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jae Sik KimDepartment of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
Bhumsuk KeamDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Dae Seog HeoDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Doo Hee HanDepartment of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.
Chae-Seo RheeDepartment of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.
Ji-Hoon KimDepartment of Radiology, Seoul National University College of Medicine, Seoul, Korea.
Kyeong Cheon JungDepartment of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Hong-Gyun WuDepartment of Radiation Oncology, Seoul National University College of Medicine, Seoul, Korea.
Seoul National University · KR

Funding

Ministry of Education, Science and Technology 50595-2018Ministry of Health and Welfare 1631200National Research Foundation of Korea 2014M2A2A7055063
6 · The paper itself

Abstract

purposeWe first analyzed the prognostic power of albumin-to-alkaline phosphatase ratio (AAPR) before radical radiotherapy (RT) in non-metastatic nasopharyngeal carcinoma (NPC) patients. MATERIALS AND

methodsThe records of 170 patients with biopsy-proven, non-metastatic NPC treated by radical RT between 1998 and 2016 at our institution were retrospectively reviewed. Median follow-up duration was 50.6 months. All patients received intensity-modulated RT and cisplatin based chemotherapy before, during, or after RT. The major treatment of patients was based on concurrent chemoradiotherapy (92.4%). The AAPR was calculated by the last value of both albumin and alkaline phosphatase within 1 month immediately preceding RT. The optimal cut-off level of AAPR was determined by using Cutoff Finder, a web-based system. Propensity score matching (PSM) analysis was performed.

resultsThe optimal cut-off level of AAPR was 0.4876. After PSM analysis of whole cohort, an AAPR was not related to survival outcomes. In PSM analysis for patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC), an AAPR ≥ 0.4876 was related to better overall survival (OS), progression-free survival (PFS), and locoregional relapse-free survival (LRRFS) (OS: hazard ratio [HR], 0.341; 95% confidence interval [CI], 0.144 to 0.805; p=0.014; PFS: HR, 0.416; 95% CI, 0.189 to 0.914; p=0.029; and LRRFS: HR, 0.243; 95% CI, 0.077 to 0.769; p=0.016, respectively).

conclusionThe AAPR, inexpensive and readily derived from a routine blood test, could be an independent prognostic factor for patients with LA-NPC. And it might help physicians determine treatment plans by identifying the patient's current status. Future prospective clinical trials to validate its prognostic value are needed.

Indexed as

Propensity ScoreAdolescentAdultAgedAlkaline PhosphataseBiomarkers, TumorChemoradiotherapyCisplatinDisease-Free SurvivalFemaleHumansMaleMiddle AgedNasopharyngeal CarcinomaNasopharyngeal NeoplasmsPrognosisAlkaline PhosphataseBiomarkers, TumorCisplatinSerum Albumin, HumanAlbumin-to-alkaline phosphatase ratioNasopharyngeal carcinomaPrognosisPropensity score matchingRadical radiotherapy

Identifiers

PMID30699498
PMCPMC6790835
OpenAlexW2912635537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.