Evidence map›Paper›PMID 30699332›Full record

ArticleNeuroscience2019

Role of Na

Wenrui Xie, Jingdong Zhang, Judith A Strong, Jun-Ming Zhang

Abstract read
In one paragraph

Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Shaping the Action Potential in Dorsal Root and Trigeminal Ganglia Neurons: Relevance to Pain Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. The Wnt/Neural plasticity · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wenrui XiePain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML0531, Cincinnati, OH 45267-0531, USA.
Jingdong ZhangPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML0531, Cincinnati, OH 45267-0531, USA.
Judith A StrongPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML0531, Cincinnati, OH 45267-0531, USA.
Jun-Ming ZhangPain Research Center, Department of Anesthesiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML0531, Cincinnati, OH 45267-0531, USA. Electronic address: Jun-Ming.Zhang@uc.edu.
Sabin Vaccine Institute · US

Funding

STUDY OF ACTIVITY-DEPENDENT SYMPATHETIC SPROUTINGR01NS045594 · NINDS · UNIVERSITY OF CINCINNATI · PI ZHANG, JUN-MING · 2004 to 2025
$8.6M
NEURAL AND CHEMICAL BASIS OF PATHOLOGIC PAINR01NS055860 · NINDS · UNIVERSITY OF CINCINNATI · PI ZHANG, JUN-MING · 2008 to 2017
$3.7M
Steroids and Steroid Receptors in Low Back PainR01AR068989 · NIAMS · UNIVERSITY OF CINCINNATI · PI ZHANG, JUN-MING · 2016 to 2020
$1.7M
NIAMS NIH HHS R01 AR068989NINDS NIH HHS R01 NS045594NINDS NIH HHS R01 NS055860
6 · The paper itself

Abstract

Low back pain is a common cause of chronic pain and disability. It is modeled in rodents by chronically compressing the lumbar dorsal root ganglia (DRG) with small metal rods, resulting in ipsilateral mechanical and cold hypersensitivity, and hyperexcitability of sensory neurons. Sodium channels are implicated in this hyperexcitability, but the responsible isoforms are unknown. In this study, we used siRNA-mediated knockdown of the pore-forming Na

Indexed as

Action PotentialsAnimalsFemaleGanglia, SpinalInflammationInflammation MediatorsLow Back PainMaleModels, AnimalNAV1.6 Voltage-Gated Sodium ChannelNeuronsPain ThresholdRats, Sprague-DawleySpinal Cord CompressionUp-RegulationVoltage-Gated Sodium Channel beta-4 SubunitInflammation MediatorsNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, ratVoltage-Gated Sodium Channel beta-4 Subunitcytokineinflammationradicular painsensory neuronspontaneous activitysympathetic nervous system

Identifiers

PMID30699332
PMCPMC6441841
OpenAlexW2911518628

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.