ArticlePLoS biology2019
Network hubs affect evolvability.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Parallel Erosion of a Testis-Specific Na+/K+ ATPase in Three Mammalian Lineages Sheds Light into the Evolution of Spermatozoa Energetics.Genome biology and evolution · 2026Article
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- Gene expression evolution is predicted by stronger indirect selection at more pleiotropic genes.Evolution letters · 2025Article
- Data-driven structural analysis of small cell lung cancer transcription factor network suggests potential subtype regulators and transition pathways.NPJ systems biology and applications · 2023Article
- Degeneracy measures in biologically plausible random Boolean networks.BMC bioinformatics · 2022Article
- Elucidating the network features and evolutionary attributes of intra- and interspecific protein-protein interactions between human and pathogenic bacteria.Scientific reports · 2021Article
- Article
- A self-consistent probabilistic formulation for inference of interactions.Scientific reports · 2020Article
- Gene Loss Predictably Drives Evolutionary Adaptation.Molecular biology and evolution · 2020Article
- Genome-wide variation and transcriptional changes in diverse developmental processes underlie the rapid evolution of seasonal adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Many functionally connected loci foster adaptive diversification along a neotropical hybrid zone.Science advances · 2020Article
- Network architectures supporting learnability.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Depicting the Core Transcriptome Modulating Multiple Abiotic Stresses Responses in Sesame (International journal of molecular sciences · 2019Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The regulatory processes in cells are typically organized into complex genetic networks. However, it is still unclear how this network structure modulates the evolution of cellular regulation. One would expect that mutations in central and highly connected modules of a network (so-called hubs) would often result in a breakdown and therefore be an evolutionary dead end. However, a new study by Koubkova-Yu and colleagues finds that in some circumstances, altering a hub can offer a quick evolutionary advantage. Specifically, changes in a hub can induce significant phenotypic changes that allow organisms to move away from a local fitness peak, whereas the fitness defects caused by the perturbed hub can be mitigated by mutations in its interaction partners. Together, the results demonstrate how network architecture shapes and facilitates evolutionary adaptation.
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