ArticleStroke2019
National Trends in Hospitalizations for Stroke Associated With Infective Endocarditis and Opioid Use Between 1993 and 2015.
Article in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Effect of a Housing Intervention on Selected Cardiovascular Risk Factors Among Homeless Adults With Mental Illness: 24-Month Follow-Up of a Randomized Controlled Trial.Journal of the American Heart Association · 2020Trial
- Temporal Trends in Ischemic Stroke Incidence in Younger Adults in the Framingham Study.Stroke · 2019Trial
- Microvascular Dysfunction, Mitochondrial Reprogramming, and Inflammasome Activation as Critical Regulators of Ischemic Stroke Severity Induced by Chronic Exposure to Prescription Opioids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Association of Opioid Prescription with Major Adverse Cardiovascular Events: Nationwide Cohort Study.Journal of clinical medicine · 2025Article
- Prevalence of Stroke - Behavioral Risk Factor Surveillance System, United States, 2011-2022.MMWR. Morbidity and mortality weekly report · 2024Article
- Opioid Impacts on Cardiovascular Health.Cureus · 2023Review
- Intravenous Drug Use-Associated Endocarditis Leads to Increased Intracranial Hemorrhage and Neurological Comorbidities.Stroke (Hoboken, N.J.) · 2023Article
- Changing Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis-Related Stroke, 2005-2015.Neurology · 2023Article
- Trends in the Incidence of Spontaneous Subarachnoid Hemorrhages in the United States, 2007-2017.Neurology · 2023Article
- A Peculiar Case of Fentanyl-Induced Cardiomyopathy.Cureus · 2022Article
- Review of Neurologic Comorbidities in Hospitalized Patients With Opioid Abuse.Neurology. Clinical practice · 2021Review
- Temporal Trends in Ischemic Stroke Rates by Ethnicity, Sex, and Age (2000-2017): The Brain Attack Surveillance in Corpus Christi Project.Neurology · 2021Article
- Association of Nonacute Opioid Use and Cardiovascular Diseases: A Scoping Review of the Literature.Journal of the American Heart Association · 2021Article
- Delayed Cerebral Abscess Formation After Posterior Cerebral Artery Stroke in a Patient With Opioid Use Disorder.Stroke · 2021Article
- Sex differences in stroke co-morbidities.Experimental neurology · 2020Review
- Disparities in United States hospitalizations for serious infections in patients with and without opioid use disorder: A nationwide observational study.PLoS medicine · 2020Observational
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6 authors at 2 institutions in 1 country.
Funding
Abstract
Background and Purpose- There has been a recent sharp rise in opioid-related deaths in the United States. Intravenous opioid use can lead to infective endocarditis (IE) which can result in stroke. There are scant data on recent trends in this neurological complication of opioid abuse. We hypothesized that increasing opioid abuse has led to a higher incidence of stroke associated with IE and opioid use. Methods- We used the 1993 to 2015 releases of the National Inpatient Sample and validated International Classification of Diseases, Ninth Revision, Clinical Modification codes ( ICD-9-CM) to identify hospitalizations with the combination of opioid abuse, IE, and stroke (defined as ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage). Survey weights provided by the National Inpatient Sample were used to calculate nationally representative estimates and population estimates from the United States. Census data were used to calculate annual hospitalization rates per 10 million person-years. Joinpoint regression was used to assess trends. Results- From 1993 through 2015, there were 5283 hospitalizations with stroke associated with IE and opioid use. Across this period, the rate of such hospitalizations increased from 2.4 (95% CI, 0.5-4.3) to 18.8 (95% CI, 14.4-23.3) per 10 million US residents. Joinpoint regression detected 2 segments: no significant change in the hospitalization rate was apparent from 1993 to 2008 (annual percentage change, 1.9%; 95% CI, -2.2% to 6.1%), and then rates significantly increased from 2008 to 2015 (annual percentage change, 20.3%; 95% CI, 10.5%-30.9%), most dramatically in non-Hispanic white patients in the Northeastern and Southern United States. Conclusions- US hospitalization rates for stroke associated with IE and opioid use were stable for ≈2 decades but then sharply increased starting in 2008, coinciding with the emergence of the opioid epidemic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.