ArticleAmerican journal of public health2019
From the Outside In: Biological Mechanisms Linking Social and Environmental Exposures to Chronic Disease and to Health Disparities.
Article in American journal of public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed.
- Trial
- Health-Related Social Needs and Cardiovascular Disease.Current cardiology reports · 2026Review
- Transcriptomic signatures of mind-body transformations therapy in breast cancer: Downregulation of the interferon signaling pathway.Breast (Edinburgh, Scotland) · 2026Article
- A quantitative intersectional approach to measuring change in built environment amenities and the association with mortality in U.S. counties.Social science & medicine (1982) · 2026Article
- Workplace Harassment and All-Cause Mortality in a Longitudinal Cohort over a 24-Year Period.Occupational Health · 2026Article
- Geographic Measures of Early Life-Course Social Exposome in the Evaluation of Structural Neuroanatomy: A Scoping Review.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Review
- Chronic Disease Prevalence and Modifiable Risk Factors Among Undergraduate Students at Ha'il University: A Population-Level Cross-Sectional Study.Risk management and healthcare policy · 2026Article
- Adverse Life Events Across the Life Course and the Risk of New-Onset Cardiovascular-Kidney-Metabolic Multimorbidity in Middle-Aged and Older Adults: Longitudinal Evidence From CHARLS.Journal of the American Heart Association · 2025Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- Characterization of Antiretroviral Therapy (ART) Adherence Phenotypes and Psychosocial Symptom Clusters Among Black/African American (AA) and Hispanic/Latine Adolescents and Young Adults (AYAs) with HIV in the Adherence Connection for Counseling, Education, and Support (ACCESS-II) Trial.Tropical medicine and infectious disease · 2025Article
- How multi-scale modeling can help examine social determinants of health and resulting disparities.PLoS computational biology · 2025Article
- Colorectal cancer survival disparities in persistent poverty areas.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
- Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora.Biomedicines · 2025Review
- Gerotherapeutics: aging mechanism-based pharmaceutical and behavioral interventions to reduce cancer racial and ethnic disparities.Journal of the National Cancer Institute · 2025Review
- Article
- Responsible research in health disparities using the Adolescent Brain Cognitive DevelopmentDevelopmental cognitive neuroscience · 2025Article
- Tweeting environmental pollution: Analyzing twitter language to uncover its correlation with county-level obesity rates in the United States.Preventive medicine · 2024Article
- Multigenerational inequalities of opportunity in health outcomes.International journal for equity in health · 2024Article
- Unpacking Neighborhood Socioeconomic Status in Children's Health Research from an Environmental Justice Perspective: A Scoping Review.Current environmental health reports · 2024Article
- Atherosclerosis and the Bidirectional Relationship between Cancer and Cardiovascular Disease: From Bench to Bedside-Part 1.International journal of molecular sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ongoing epidemic of chronic diseases involves a spectrum of clinical entities now understood to represent late manifestations of progressive metabolic dysfunction initiated in early life. These diseases disproportionately affect disadvantaged populations, exacerbating health disparities that persist despite public health efforts. Excessive exposure to stressful psychosocial and environmental forces is 1 factor known to contribute to population-level disparities in at-risk settings. Yet increasing evidence reveals that even a single adverse environmental exposure-especially during very early developmental years-can become literally biologically embedded, inducing long-lasting disease-promoting pathways that amplify responses (e.g., cortisol, immune, inflammatory) to all future adverse stressors, thus enhancing their disease-promoting impacts. The same pathways may also interact with ancestrally linked genetic variants to modify chronic disease risk. We address how, in at-risk populations, environmentally activated disease-promoting pathways can contribute to a biologically based disease-susceptible phenotype; this is likely to be uniquely damaging in populations with multiple adverse exposures and is capable of cross-generational transmission. Intended to complement existing models, this biological perspective highlights key research opportunities and life-stage priorities with potential to enhance the reduction of health disparities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.