Evidence map›Paper›PMID 30698943›Full record

ArticleACS chemical neuroscience2019

Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([

Hualong Fu, Weiting Tang, Zhen Chen, Vasily V Belov, Genwei Zhang, Tuo Shao, Xiaofei Zhang, Qingzhen Yu, Jian Rong, Xiaoyun Deng and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Selective Cell-Surface Expression of Triheteromeric NMDA Receptors.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  3. First-in-Humans Brain PET Imaging of the GluN2B-ContainingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  4. A Review of Molecular Imaging of Glutamate Receptors.Molecules (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Hualong FuDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Weiting TangDepartment of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
Zhen ChenDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.ORCID 0000-0002-6289-4332
Vasily V BelovDepartment of Radiology, Massachusetts General Hospital , Harvard Medical School, and the Shriners Burns Hospital , Boston , Massachusetts 02114 , United States.
Genwei ZhangDepartment of Chemistry and Biochemistry , University of Oklahoma , Norman , Oklahoma 73019 , United States.
Tuo ShaoDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Xiaofei ZhangDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Qingzhen YuDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Jian RongDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Xiaoyun DengDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Wei HanDepartment of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
Scott J MyersDepartment of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
Pilar GiffenigDepartment of Radiology, Massachusetts General Hospital , Harvard Medical School, and the Shriners Burns Hospital , Boston , Massachusetts 02114 , United States.
Lu WangDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Lee JosephsonDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.
Yihan ShaoDepartment of Chemistry and Biochemistry , University of Oklahoma , Norman , Oklahoma 73019 , United States.ORCID 0000-0001-9337-341X
April T DavenportDepartment of Physiology and Pharmacology, Wake Forest School of Medicine , Winston Salem , North Carolina 27157 , United States.
James B DaunaisDepartment of Physiology and Pharmacology, Wake Forest School of Medicine , Winston Salem , North Carolina 27157 , United States.
Mikhail PapisovDepartment of Radiology, Massachusetts General Hospital , Harvard Medical School, and the Shriners Burns Hospital , Boston , Massachusetts 02114 , United States.
Hongjie YuanDepartment of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.
Zijing LiState Key Laboratory of Molecular Vaccinology, Molecular Diagnosis & Center for Molecular Imaging and Translational Medicine, School of Public Health , Xiamen University , Xiamen 361102 , P. R. China.ORCID 0000-0003-2156-6479
Stephen F TraynelisDepartment of Pharmacology , Emory University School of Medicine , Atlanta , Georgia 30322 , United States.ORCID 0000-0002-3750-9615
Steven H LiangDepartment of Radiology, Division of Nuclear Medicine and Molecular Imaging , Massachusetts General Hospital and Harvard Medical School , 55 Fruit Street , Boston , Massachusetts 02114 , United States.ORCID 0000-0003-1413-6315

Funding

Monkey Alcohol Tissue Research Resource (MATRR)R24AA019431 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Mary Lauren Benton, Verginia Carmella Cuzon Carlson · 2010 to 2026
$10.3M
Early Stress & Alcoholism: Neurobiological AnalysisU01AA014106 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FRIEDMAN, DAVID P · 2003 to 2011
$3.4M
Mechanism of Action of Novel Subunit-Selective NMDA Receptor ModulatorsR01NS065371 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 2009 to 2018
$3.4M
NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted TherapyR01HD082373 · NICHD · EMORY UNIVERSITY · PI YUAN, HONGJIE · 2015 to 2025
$3.3M
NIAAA NIH HHS R24 AA019431NIAAA NIH HHS U01 AA014106NICHD NIH HHS R01 HD082373NINDS NIH HHS R01 NS065371
6 · The paper itself

Abstract

GluN2B is the most studied subunit of N-methyl-d-aspartate receptors (NMDARs) and implicated in the pathologies of various central nervous system disorders and neurodegenerative diseases. As pan NMDAR antagonists often produce debilitating side effects, new approaches in drug discovery have shifted to subtype-selective NMDAR modulators, especially GluN2B-selective antagonists. While positron emission tomography (PET) studies of GluN2B-selective NMDARs in the living brain would enable target engagement in drug development and improve our understanding in the NMDAR signaling pathways between normal and disease conditions, a suitable PET ligand is yet to be identified. Herein we developed an

Indexed as

TriazolesAnimalsAutoradiographyBrainFluorine RadioisotopesPositron-Emission TomographyRadiopharmaceuticalsRatsReceptors, N-Methyl-D-AspartateFluorine RadioisotopesNR2B NMDA receptorRadiopharmaceuticalsReceptors, N-Methyl-D-AspartateTriazoles18F-labelingautoradiographyGluN2B subunitPET imagingspirocyclic iodonium ylideSubtype-selective

Identifiers

PMID30698943
PMCPMC6727982

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.