Brainstem spreading depolarization: rapid descent into the shadow of SUDEP.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

13 citing papers in PubMed.

1. Tsunamis hiding in plain sight: spreading depression in clinical neurology.Nature reviews. Neurology · 2026
   Review
2. Loss of cyclin-dependent kinase-like 5 results in susceptibility to audiogenic seizures in mice.Epilepsia open · 2026
   Article
3. Respiratory dysfunction and fatal apnea during pilocarpine-induced status epilepticus.Epilepsia · 2026
   Article
4. Astrocytes at the interface of peri-ictal breathing dysfunction and SUDEP.Frontiers in network physiology · 2026
   Review
5. Multiomic Analyses Reveal Brainstem Metabolic Changes in a Mouse Model of Dravet Syndrome.Cells · 2025
   Article
6. Hippocampal infarction and generalized seizures predict early mortality after endovascular middle cerebral artery occlusion in mice.Experimental neurology · 2024
   Article
7. A unified hypothesis of SUDEP: Seizure-induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and other restorative respiratory response mechanisms mediated by the action of serotonin on the periaqueductal gray.Epilepsia · 2023
   Review
8. Development of Mechanistic Neural Mass (mNM) Models that Link Physiology to Mean-Field Dynamics.Frontiers in network physiology · 2022
   Article
9. Limbic and paralimbic respiratory modulation: From inhibition to enhancement.Epilepsia · 2022
   Article
10. Autonomic dysfunction in epilepsy mouse models with implications for SUDEP research.Frontiers in neurology · 2022
    Review
11. Review: Neuropathology findings in autonomic brain regions in SUDEP and future research directions.Autonomic neuroscience : basic & clinical · 2021
    Review
12. Polyglucosan bodies in medullary catecholaminergic neurones in SUDEP.Epilepsy & behavior reports · 2021
    Article
13. Characterisation of medullary astrocytic populations in respiratory nuclei and alterations in sudden unexpected death in epilepsy.Epilepsy research · 2019
    Article

Corrections and comments

• Comment on
  Brainstem spreading depolarization and cortical dynamics during fatal seizures in Cacna1a S218L mice.2019

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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