Evidence map›Paper›PMID 30698636›Full record

ArticleJAMA psychiatry2019

Risk of Posttraumatic Stress Disorder and Major Depression in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study.

Murray B Stein, Sonia Jain, Joseph T Giacino, Harvey Levin, Sureyya Dikmen, Lindsay D Nelson, Mary J Vassar, David O Okonkwo, Ramon Diaz-Arrastia, Claudia S Robertson and 71 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
171citing papers in PubMed, 7 pooled it
20.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

171 citing papers in PubMed, 7 syntheses or guidelines pooled it, 283 citations in OpenAlex.

  1. Pooled it
  2. Guideline
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  9. Memory Perfectionism is Associated with Persistent Memory Complaints after Concussion.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2022
    Trial
  10. Review
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  17. Effect of Traumatic Brain Injury on Sensorimotor Gating.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
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111 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

81 authors at 17 institutions in 1 country.

Murray B SteinDepartment of Psychiatry, University of California San Diego, La Jolla.
Sonia JainDepartment of Family Medicine & Public Health, University of California San Diego, La Jolla.
Joseph T GiacinoDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts.
Harvey LevinDepartment of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas.
Sureyya DikmenDepartment of Rehabilitation Medicine, University of Washington, Seattle.
Lindsay D NelsonDepartments of Neurosurgery and Neurology, Medical College of Wisconsin, Milwaukee.
Mary J VassarBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
David O OkonkwoDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania, Philadelphia.
Claudia S RobertsonDepartment of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas.
Pratik MukherjeeBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
Michael McCreaDepartments of Neurosurgery and Neurology, Medical College of Wisconsin, Milwaukee.
Christine L Mac DonaldDepartment of Neurological Surgery, University of Washington, Seattle.
John K YueBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
Esther YuhBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
Xiaoying SunDepartment of Family Medicine & Public Health, University of California San Diego, La Jolla.
Laura Campbell-SillsDepartment of Psychiatry, University of California San Diego, La Jolla.
Nancy TemkinDepartment of Neurological Surgery, University of Washington, Seattle.
Geoffrey T ManleyBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
TRACK-TBI Investigators
Opeolu AdeoyeUniversity of Cincinnati, Cincinnati, Ohio.
Neeraj BadjatiaUniversity of Maryland, College Park.
Kim BoaseDepartment of Rehabilitation Medicine, University of Washington, Seattle.
Yelena BodienMassachusetts General Hospital, Boston.
M Ross BullockUniversity of Miami, Coral Gables, Florida.
Randall ChesnutDepartment of Neurological Surgery, University of Washington, Seattle.
John D CorriganOhio State University, Columbus.
Karen CrawfordUniversity of Southern California, Los Angeles.
Ramon Diaz-ArrastiaDepartment of Neurology, University of Pennsylvania, Philadelphia.
Sureyya DikmenDepartment of Rehabilitation Medicine, University of Washington, Seattle.
Ann-Christine DuhaimeMassGeneral Hospital for Children, Boston.
Richard EllenbogenDepartment of Neurological Surgery, University of Washington, Seattle.
V Ramana FeeserDepartment of Emergency Medicine, Virginia Commonwealth University, Richmond.
Adam FergusonDepartment of Neurological Surgery, University of California, San Francisco.
Brandon ForemanUniversity of Cincinnati, Cincinnati, Ohio.
Raquel GardnerDepartment of Neurology, University of California, San Francisco.
Etienne GaudetteUniversity of Southern California, Los Angeles.
Joseph T GiacinoDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts.
Luis GonzalezTIRR Memorial Hermann, Houston, Texas.
Shankar GopinathDepartment of Neurosurgery, Baylor College of Medicine, Houston, Texas.
Rao GullapalliUniversity of Maryland, College Park.
J Claude HemphillDepartment of Neurology, University of California, San Francisco.
Gillian HotzUniversity of Miami, Coral Gables, Florida.
Sonia JainDepartment of Family Medicine & Public Health, University of California San Diego, La Jolla.
Frederick KorleyDepartment of Emergency Medicine, University of Michigan Medical School, Ann Arbor.
Joel KramerDepartment of Neurology, University of California, San Francisco.
Natalie KreitzerUniversity of Cincinnati, Cincinnati, Ohio.
Harvey LevinDepartment of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas.
Chris LindsellDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
Joan MachamerDepartment of Rehabilitation Medicine, University of Washington, Seattle.
Christopher MaddenDepartment of Neurological Surgery, UT Southwestern Medical Center, Dallas, Texas.
Alastair MartinDepartment of Radiology & Biomedical Imaging, University of California, San Francisco.
Thomas McAllisterDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis.
Michael McCreaDepartments of Neurosurgery and Neurology, Medical College of Wisconsin, Milwaukee.
Randall MerchantDepartment of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond.
Pratik MukherjeeBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
Lindsay D NelsonDepartments of Neurosurgery and Neurology, Medical College of Wisconsin, Milwaukee.
Florence NoelDan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, Texas.
David O OkonkwoDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Eva PalaciosDepartment of Radiology & Biomedical Imaging, University of California, San Francisco.
Daniel PerlDepartment of Pathology, Uniformed Services University, Bethesda, Maryland.
Ava PuccioDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Miri RabinowitzDepartment of Neurology, University of Pennsylvania, Philadelphia.
Claudia S RobertsonDepartment of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas.
Jonathan RosandMassachusetts General Hospital, Boston.
Angelle SanderDepartment of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, Texas.
Gabriela SatrisBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
David SchnyerDepartment of Psychology, University of Texas at Austin, Austin.
Seth SeaburyUniversity of Southern California, Los Angeles.
Mark ShererTIRR Memorial Hermann, Houston, Texas.
Murray B SteinDepartment of Psychiatry, University of California San Diego, La Jolla.
Sabrina TaylorDepartment of Neurological Surgery, University of California, San Francisco.
Arthur TogaUniversity of Southern California, Los Angeles.
Nancy TemkinDepartment of Neurological Surgery, University of Washington, Seattle.
Alex ValadkaDepartment of Neurosurgery, Virginia Commonwealth University, Richmond.
Mary J VassarBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
Paul VespaDepartment of Neurology, University of California Los Angeles School of Medicine, Los Angeles.
Kevin WangDepartment of Psychiatry, University of Florida, Gainesville.
John K YueBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
Esther YuhBrain and Spinal Cord Injury Center, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
Ross ZafonteDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts.
San Francisco General Hospital · USUniversity of Washington · USBaylor College of Medicine · USUniversity of California, San Francisco · USUniversity of Southern California · USUniversity of California San Diego · USUniversity of Miami · USMedical College of Wisconsin · USMemorial Hermann Institute for Rehabilitation and Research Foundation · USVirginia Commonwealth University · USHarvard University · USUniformed Services University of the Health Sciences · USUniversity of Cincinnati · USUniversity of Pittsburgh Medical Center · USUniversity of California, Los Angeles · USUniversity of Michigan · USUniversity of Pennsylvania · US

Funding

Cerebrovascular Fellowship Training ProgramT32NS047996 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Stacie Demel · 2006 to 2026
$3.7M
NINDS NIH HHS T32 NS047996
6 · The paper itself

Abstract

Importance: Traumatic brain injury (TBI) has been associated with adverse mental health outcomes, such as posttraumatic stress disorder (PTSD) and major depressive disorder (MDD), but little is known about factors that modify risk for these psychiatric sequelae, particularly in the civilian sector. Objective: To ascertain prevalence of and risk factors for PTSD and MDD among patients evaluated in the emergency department for mild TBI (mTBI). Design, Setting, and Participants: Prospective longitudinal cohort study (February 2014 to May 2018). Posttraumatic stress disorder and MDD symptoms were assessed using the PTSD Checklist for DSM-5 and the Patient Health Questionnaire-9 Item. Risk factors evaluated included preinjury and injury characteristics. Propensity score weights-adjusted multivariable logistic regression models were performed to assess associations with PTSD and MDD. A total of 1155 patients with mTBI (Glasgow Coma Scale score, 13-15) and 230 patients with nonhead orthopedic trauma injuries 17 years and older seen in 11 US hospitals with level 1 trauma centers were included in this study. Main Outcomes and Measures: Probable PTSD (PTSD Checklist for DSM-5 score, ≥33) and MDD (Patient Health Questionnaire-9 Item score, ≥15) at 3, 6, and 12 months postinjury. Results: Participants were 1155 patients (752 men [65.1%]; mean [SD] age, 40.5 [17.2] years) with mTBI and 230 patients (155 men [67.4%]; mean [SD] age, 40.4 [15.6] years) with nonhead orthopedic trauma injuries. Weights-adjusted prevalence of PTSD and/or MDD in the mTBI vs orthopedic trauma comparison groups at 3 months was 20.0% (SE, 1.4%) vs 8.7% (SE, 2.2%) (P < .001) and at 6 months was 21.2% (SE, 1.5%) vs 12.1% (SE, 3.2%) (P = .03). Risk factors for probable PTSD at 6 months after mTBI included less education (adjusted odds ratio, 0.89; 95% CI, 0.82-0.97 per year), being black (adjusted odds ratio, 5.11; 95% CI, 2.89-9.05), self-reported psychiatric history (adjusted odds ratio, 3.57; 95% CI, 2.09-6.09), and injury resulting from assault or other violence (adjusted odds ratio, 3.43; 95% CI, 1.56-7.54). Risk factors for probable MDD after mTBI were similar with the exception that cause of injury was not associated with increased risk. Conclusions and Relevance: After mTBI, some individuals, on the basis of education, race/ethnicity, history of mental health problems, and cause of injury were at substantially increased risk of PTSD and/or MDD. These findings should influence recognition of at-risk individuals and inform efforts at surveillance, follow-up, and intervention.

Indexed as

AdolescentAdultBrain Injuries, TraumaticCase-Control StudiesComorbidityEmergency Service, HospitalFemaleGlasgow Coma ScaleHumansLongitudinal StudiesMajor Depressive DisorderMalePrevalenceProspective StudiesRisk FactorsStress Disorders, Post-Traumatic

Identifiers

PMID30698636
PMCPMC6439818
OpenAlexW2912370667

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.