ArticleSoft matter2019
Drug release from thin films encapsulated by a temperature-responsive hydrogel.
Article in Soft matter, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed.
- Recent advances in technologies for the controlled release of aromatic compounds: From encapsulation to electrospinning.Current research in food science · 2026Review
- Controlled Release and Antibacterial Performance of Terpinen-4-ol/β-CD Liquid Bandages.ACS omega · 2025Article
- Direct Metal Transfer on Swellable Hydrogel with Dehydration-Induced Physical Adhesion.ACS omega · 2024Article
- Luteinizing Hormone-Releasing Hormone (LHRH)-Conjugated Cancer Drug Delivery from Magnetite Nanoparticle-Modified Microporous Poly-Di-Methyl-Siloxane (PDMS) Systems for the Targeted Treatment of Triple Negative Breast Cancer Cells.Journal of functional biomaterials · 2024Article
- Hydrogel-Based Therapy for Age-Related Macular Degeneration: Current Innovations, Impediments, and Future Perspectives.Gels (Basel, Switzerland) · 2024Review
- Gels in Motion: Recent Advancements in Energy Applications.Gels (Basel, Switzerland) · 2024Review
- In-vivo studies of targeted and localized cancer drug release from microporous poly-di-methyl-siloxane (PDMS) devices for the treatment of triple negative breast cancer.Scientific reports · 2024Article
- Smart responsiveFrontiers in bioengineering and biotechnology · 2024Review
- Stereo-Complex and Click-Chemical Bicrosslinked Amphiphilic Network Gels with Temperature/pH Response.Gels (Basel, Switzerland) · 2023Article
- Stimuli-responsive hydrogels: smart state of-the-art platforms for cardiac tissue engineering.Frontiers in bioengineering and biotechnology · 2023Review
- Glucose-Responsive Boronic Acid Hydrogel Thin Films Obtained via Initiated Chemical Vapor Deposition.Biomacromolecules · 2022Article
- Environmentally responsive hydrogels for repair of cardiovascular tissue.Heart failure reviews · 2021Review
- Initiated Chemical Vapor Deposition Kinetics of Poly(4-aminostyrene).Frontiers in bioengineering and biotechnology · 2021Article
- Controlled Release Utilizing Initiated Chemical Vapor Deposited (iCVD) of Polymeric Nanolayers.Frontiers in bioengineering and biotechnology · 2021Review
- Cooling-Triggered Release from Mesoporous Poly(ACS applied materials & interfaces · 2020Article
- An Updated Review of Macro, Micro, and Nanostructured Hydrogels for Biomedical and Pharmaceutical Applications.Pharmaceutics · 2020Review
- Conformal Coating of Powder by Initiated Chemical Vapor Deposition on Vibrating Substrate.Pharmaceutics · 2020Article
- Applicability of Vapor-Deposited Thermoresponsive Hydrogel Thin Films in Ultrafast Humidity Sensors/Actuators.ACS applied polymer materials · 2020Article
- Initiated Chemical Vapor Deposition of Crosslinked Organic Coatings for Controlling Gentamicin Delivery.Pharmaceutics · 2020Article
- A Double-Switch Temperature-Sensitive Controlled Release Antioxidant Film Embedded with Lyophilized Nanoliposomes Encapsulating Rosemary Essential Oils for Solid Food.Materials (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Control over drug delivery may be interestingly achieved by using temperature responsive encapsulants, which change their thickness and mesh size with temperature. The prototype N-isopropylacrylamide hydrogel cross-linked with di(ethylene glycol) divinyl ether p(NIPAAm-co-DEGDVE) swells at low temperature and collapses above the lower critical solution temperature (LCST), ∼29 °C in a buffer. It might be expected that drug release from such encapsulation is always favored below the LCST, due to the larger free volume present in the swollen polymer film. Recent results show contradicting behavior where some cases behave as expected and others release much less when the polymer layer is swollen. In this study, layers of the drugs phenytoin, clotrimazole and indomethacin were drop cast on glass and p(NIPAAM-co-DEGDVE) layers were then synthesized directly on top of these drug layers via initiated chemical vapor deposition (iCVD), a solvent-free and gentle polymerization technique. Dissolution experiments were then performed, in which the drug release through the hindrance of the hydrogel was measured at different pH values. The results show that not only the swelling but also the permeate (drug in this case)-polymer interaction plays an important role in the release.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.