ArticleJournal of the American Chemical Society2019
Development of a Terpene Feedstock-Based Oxidative Synthetic Approach to the Illicium Sesquiterpenes.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 91 citations in OpenAlex.
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- Chemoenzymatic Skeletal Editing of Natural Product Scaffolds via P450-Controlled Site-Selective Ring Expansion at Aliphatic C─H Sites.Angewandte Chemie (International ed. in English) · 2025Article
- Synthesis of diverse terpenoid frameworks via enzyme-enabled abiotic scaffold hop.Nature chemistry · 2025Article
- Total Synthesis of (-)-Illisimonin A Enabled by Pattern Recognition and Olefin Transposition.Journal of the American Chemical Society · 2025Article
- Bioinspired concise synthesis of caged Sesquiterpenoids Artatrovirenols A and B.Nature communications · 2025Article
- Recent advances in total synthesis of illisimonin A.Beilstein journal of organic chemistry · 2025Review
- Discovery, Characterization and Synthetic Application of a Promiscuous Nonheme Iron Biocatalyst with Dual Hydroxylase/Desaturase Activity.Angewandte Chemie (International ed. in English) · 2024Article
- Molecular complexity as a driving force for the advancement of organic synthesis.Nature reviews. Chemistry · 2024Review
- Intramolecular C-H Oxidation in Iron(V)-oxo-carboxylato Species Relevant in the γ-Lactonization of Alkyl Carboxylic Acids.ACS catalysis · 2024Article
- Natural Product Synthesis: The Endless Quest for Unreachable Perfection.ACS organic & inorganic Au · 2023Review
- Strategic application of C-H oxidation in natural product total synthesis.Nature reviews. Chemistry · 2023Review
- Article
- Highly Enantioselective Catalytic Lactonization at Nonactivated Primary and SecondaryJournal of the American Chemical Society · 2023Article
- Asymmetric Total Synthesis of Illisimonin A.Journal of the American Chemical Society · 2023Article
- Carboxylic Acid Directed γ-Lactonization of Unactivated Primary C-H Bonds Catalyzed by Mn Complexes: Application to Stereoselective Natural Product Diversification.Journal of the American Chemical Society · 2022Article
- Unified Total Syntheses of Benzenoid Cephalotane-Type Norditerpenoids: Cephanolides and Ceforalides.Journal of the American Chemical Society · 2022Article
- Total Synthesis of Natural Terpenoids Enabled by Cobalt Catalysis.Frontiers in chemistry · 2022Review
- Change the channel: CysLoop receptor antagonists from nature.Pest management science · 2021Review
- Radical philicity and its role in selective organic transformations.Nature reviews. Chemistry · 2021Review
- Dearomative Synthetic Entry into the Altemicidin Alkaloids.Journal of the American Chemical Society · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The Illicium sesquiterpenes are a family of natural products containing over 100 highly oxidized and structurally complex members, many of which display interesting biological activities. This comprehensive account chronicles the evolution of a semisynthetic strategy toward these molecules from (+)-cedrol, seeking to emulate key aspects of their presumed biosynthesis. An initial route generated lower oxidation state analogs but failed in delivering a crucial hydroxy group in the final step. Insight gathered during these studies, however, ultimately led to a synthesis of the pseudoanisatinoids along with the allo-cedrane natural product 11- O-debenzoyltashironin. A second-generation strategy was then developed to access the more highly oxidized majucinoid compounds including jiadifenolide and majucin itself. Overall, one dozen natural products can be accessed from an abundant and inexpensive terpene feedstock. A multitude of general observations regarding site-selective C(sp
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.