ReviewJournal of occupational health2019
Comprehensive review of 2-ethyl-1-hexanol as an indoor air pollutant.
Review in Journal of occupational health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Ranking sources of indoor volatile organic compounds by attributable burden of disease in China.Journal of exposure science & environmental epidemiology · 2026Article
- Developing Quick Screening Method to Identify Rice Cultivars with Unique Aromatic Features.ACS omega · 2026Article
- Chronic inhalation exposure to 0.5 ppm of 2-ethyl-1-hexanol induces histopathological changes in olfactory, respiratory, and skin tissue of mice.Journal of occupational health · 2026Article
- Occupational Exposure to Volatile Organic Compounds in Polyurethane Foam Production-Concentration, Variability and Health Risk Assessment.Molecules (Basel, Switzerland) · 2026Article
- Indoor Airborne VOCs from Water-Based Coatings: Transfer Dynamics and Health Implications.Journal of xenobiotics · 2025Article
- Liver-specific propanoate metabolism-derived 2-ethylhexanol as a novel biomarker for precise diagnosis and prognosis of hepatocellular carcinoma.Biomarker research · 2025Article
- An olfactory model for evaluating the larviposition preference of a vector fly.Insect science · 2025Article
- Volatile Organic Compound (VOC) Contamination in Hotel Rooms: A Pilot Study to Understand Sources and Health Risks.International journal of environmental research and public health · 2024Article
- Detection and Validation of Organic Metabolites in Urine for Clear Cell Renal Cell Carcinoma Diagnosis.Metabolites · 2024Article
- Biomarker Predictors of Clinical Efficacy of the Anti-IgE Biologic Omalizumab in Severe Asthma in Adults: Results of the SoMOSA Study.American journal of respiratory and critical care medicine · 2024Article
- Examination of internal metabolome and VOCs profile of brewery yeast and their mutants producing beer with improved aroma.Scientific reports · 2024Article
- Predicting Chronological Age via the Skin Volatile Profile.Journal of the American Society for Mass Spectrometry · 2024Article
- Physical properties of odorants affect behavior of trained detection dogs during close-quarters searches.Scientific reports · 2024Article
- Article
- Human skin gas profile of individuals with the people allergic to me phenomenon.Scientific reports · 2023Article
- Markers of Chemical and Microbiological Contamination of the Air in the Sport Centers.Molecules (Basel, Switzerland) · 2023Article
- Effect of olive by-products feed supplementation on physicochemical and microbiological profile of Provola cheese.Frontiers in microbiology · 2023Article
- Seaweed Inclusion in Finishing Lamb Diet Promotes Changes in Micronutrient Content and Flavour-Related Compounds of Raw Meat and Dry-Cured Leg (Fenalår).Foods (Basel, Switzerland) · 2022Article
- Article
- Inhalation exposure to 2-ethyl-1-hexanol causes hepatomegaly and transient lipid accumulation without induction of peroxisome proliferator-activated receptor alpha in mice.Industrial health · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectives2-Ethyl-1-hexanol (2EH), a fragrance ingredient and a raw material for the production of plasticizer di(2-ethylhexyl) phthalate, is responsible for sick building syndrome (SBS). This review aims to clarify the 2EH characteristics as an indoor air pollutant such as indoor air concentration, emission mechanism, toxicity, and clinical effects.
methodsScientific publications in English that has been made available on PubMed as of June 2018 and ad hoc publications in regional languages were reviewed.
resultsInhalation exposure to 2EH caused mucous membrane irritation in the eyes, nose, and throat in experimental animals. Studies in human volunteers revealed an increase in olfactory irritation and eye discomfort. There has been increasing evidence of 2EH being present in indoor air in buildings. The primary sources of 2EH emissions are not building materials themselves, but instead the hydrolysis of plasticizers and flooring adhesives. In particular, compounds like di(2-ethylhexyl) phthalate present in polyvinyl chloride flooring materials are hydrolyzed upon contact with alkaline moisture-containing concrete floors. That being said, it may be observed that indoor concentrations of 2EH increased every year during summer.
conclusionsUnlike other volatile organic compounds that cause SBS, 2EH can be retained in indoor air for long durations, increasing the likelihood of causing undesirable health effects in building occupants exposed to it. As a precautionary measure, it is important to use flooring materials that do not emit 2EH by hydrolysis, or to dry concrete before covering with flooring materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.