Evidence map›Paper›PMID 30698141›Full record

ArticleeLife2019

Comment on 'Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity'.

Maurizio Pacifici, Eileen M Shore

Abstract readComment
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Maurizio PacificiTranslational Research Program in Pediatric Orthopaedics, The Children's Hospital of Philadelphia, Philadelphia, United States.ORCID 0000-0001-6854-4942
Eileen M ShoreDepartment of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-2609-6971

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We are writing to communicate our concerns regarding the recently published study by Lees-Shepard et al. (2018).

Indexed as

Myositis OssificansOssification, HeterotopicStilbenesAnimalsMicePyrazolesPalovarotenePyrazolesStilbenesdrug treatmenthuman biologymedicinemousepalovarotenerare skeleatal disorders

Identifiers

PMID30698141
PMCPMC6353590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.