Evidence map›Paper›PMID 30698127›Full record

ArticleTwin research and human genetics : the official journal of the International Society for Twin Studies2019

The Genetic and Environmental Relationship Between Childhood Behavioral Inhibition and Preadolescent Anxiety.

Jessica L Bourdon, Jeanne E Savage, Brad Verhulst, Dever M Carney, Melissa A Brotman, Daniel S Pine, Ellen Leibenluft, Roxann Roberson-Nay, John M Hettema

Open access · bronzeAbstract readTwin Study
In one paragraph

Article in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Peer and familial influences on the association between behavioral inhibition and trajectories of social anxiety symptoms across adolescence.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026
    Article
  3. Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Article
  4. Genetic Vulnerability to Social Anxiety Disorder.Current topics in behavioral neurosciences · 2025
    Review
  5. Article
  6. Article
  7. Validation of the Italian Version of the Behavioral Inhibition Questionnaire (BIQ) for Preschool Children.International journal of environmental research and public health · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jessica L BourdonVirginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA.
Jeanne E SavageVirginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA.
Brad VerhulstVirginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA.
Dever M CarneyVirginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA.
Melissa A BrotmanEmotion and Development Branch,National Institute of Mental Health, National Institutes of Health,Department of Health and Human Services, Bethesda, MD,USA.
Daniel S PineEmotion and Development Branch,National Institute of Mental Health, National Institutes of Health,Department of Health and Human Services, Bethesda, MD,USA.
Ellen LeibenluftEmotion and Development Branch,National Institute of Mental Health, National Institutes of Health,Department of Health and Human Services, Bethesda, MD,USA.
Roxann Roberson-NayVirginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA.
John M HettemaVirginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond, VA,USA.
Virginia Commonwealth University · USNational Institute of Mental Health · USNational Institutes of Health · US

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Fmri Studies Of Risk For Mood And Anxiety Disorders In ChildrenZIAMH002782 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$28.3M
Unit on Neuroscience and Novel TherapeuticsZIAMH002969 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BROTMAN, MELISSA · 2019 to 2025
$13.8M
Research Training: Psychiatric &Statistical GeneticsT32MH020030 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HERMINE H MAES, MICHAEL CHURTON NEALE · 1999 to 2026
$6.7M
A Twin Study of Negative Valence Emotional ConstructsR01MH098055 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI HETTEMA, JOHN M · 2012 to 2014
$1.6M
NIMH NIH HHS R01 MH098055NIMH NIH HHS T32 MH020030NIMH NIH HHS ZIA MH002781
6 · The paper itself

Abstract

This study uses novel approaches to examine genetic and environmental influences shared between childhood behavioral inhibition (BI) and symptoms of preadolescent anxiety disorders. Three hundred and fifty-two twin pairs aged 9-13 and their mothers completed questionnaires about BI and anxiety symptoms. Biometrical twin modeling, including a direction-of-causation design, investigated genetic and environmental risk factors shared between BI and social, generalized, panic and separation anxiety. Social anxiety shared the greatest proportion of genetic (20%) and environmental (16%) variance with BI with tentative evidence for causality. Etiological factors underlying BI explained little of the risk associated with the other anxiety domains. Findings further clarify etiologic pathways between BI and anxiety disorder domains in children.

Indexed as

Gene-Environment InteractionInhibition, PsychologicalSurveys and QuestionnairesAdolescentAnxiety DisordersChildFemaleHumansMaleTwins, DizygoticTwins, Monozygoticanxietybehavioral inhibitiontwins

Identifiers

PMID30698127
PMCPMC6449201
OpenAlexW2914158028

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.