ArticleJournal of research on adolescence : the official journal of the Society for Research on Adolescence2020
A SNP, Gene, and Polygenic Risk Score Approach of Oxytocin-Vasopressin Genes in Adolescents' Loneliness.
Article in Journal of research on adolescence : the official journal of the Society for Research on Adolescence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Overexpression of Hspa1b in the mouse hippocampus may be associated with major depressive disorder.Behavioral and brain functions : BBF · 2025Article
- The role of the immune system in early-onset schizophrenia: identifying immune characteristic genes and cells from peripheral blood.BMC immunology · 2024Article
- The Effect of Peer Relationships on Adolescent Loneliness: The Role of Psychological Resilience and the OXTR Gene.Psychology research and behavior management · 2024Article
- Neurogenetics and Epigenetics of Loneliness.Psychology research and behavior management · 2023Review
- Article
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11 authors.
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Abstract
Not much is known regarding underlying biological pathways to adolescents' loneliness. Insight in underlying molecular mechanisms could inform intervention efforts aimed at reducing loneliness. Using latent growth curve modeling, baseline levels and development of loneliness were studied in two longitudinal adolescent samples. Genes (OXTR, OXT, AVPR1A, AVPR1B) were examined using SNP-based, gene-based, and polygenic risk score (PRS) approaches. In both samples, SNP- and gene-based tests showed involvement of the OXTR gene in development of loneliness, though, significance levels did not survive correction for multiple testing. The PRS approach provided no evidence for relations with loneliness. We recommend alternative phenotyping methods, including environmental factors, to consider epigenetic studies, and to examine possible endophenotypes in relation to adolescents' loneliness.
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