ArticleJournal of veterinary internal medicine2019
Phenotypic, hormonal, and clinical characteristics of equine endocrinopathic laminitis.
Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Risk factors for equine strangulating lipoma colic: An international, case-control study.Equine veterinary journal · 2026Article
- High molecular weight adiponectin as an adjunct biomarker for insulin dysregulation in equids.Journal of veterinary internal medicine · 2026Article
- The Effect of Lipemia on Insulin and Adiponectin Measurement in Equine Blood Samples.Veterinary clinical pathology · 2026Article
- Associations among beta-endorphin, ACTH, cortisol concentration, age, and clinical signs indicative of pituitary pars intermedia dysfunction in geriatric horses.Journal of veterinary internal medicine · 2026Article
- Assessment of baseline adrenocorticotropic hormone and insulin concentrations in healthy horses in Saskatchewan over a 1-year period.Journal of veterinary internal medicine · 2026Article
- Forage Carbohydrate Profiles and Endocrine Morphometric Interactions in Traditionally Managed Horses from Romania.Life (Basel, Switzerland) · 2025Article
- Effect of pergolide treatment on insulin dysregulation in horses and ponies with pituitary pars intermedia dysfunction.Equine veterinary journal · 2025Article
- Prevalence and Progression of Resting ACTH, Insulin and Adiponectin Values as Indicators of Suspected Endocrine Diseases in Sport Horses and Ponies Compared to Non-Sport Horses, Ponies and Donkeys.Animals : an open access journal from MDPI · 2025Article
- Nutraceutical Supplement Mitigates Insulin Resistance in Horses with a History of Insulin Dysregulation During a Challenge with a High-Starch Diet.Animals : an open access journal from MDPI · 2024Article
- Occurrence of equine metabolic syndrome, clinical manifestations, and associated risk factors in Nigeria.Journal of equine science · 2023Article
- Clinical evaluation of the Immulite® 1000 chemiluminescent immunoassay for measurement of equine serum insulin.Frontiers in veterinary science · 2023Article
- Article
- Incidence and risk factors for recurrence of endocrinopathic laminitis in horses.Journal of veterinary internal medicine · 2019Article
- Phenotypic, hormonal, and clinical characteristics of equine endocrinopathic laminitis.Journal of veterinary internal medicine · 2019Article
- An investigation of the equine epidermal growth factor system during hyperinsulinemic laminitis.PloS one · 2019Article
- Effect of 5'-adenosine monophosphate-activated protein kinase agonists on insulin and glucose dynamics in experimentally induced insulin dysregulation in horses.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundEquine endocrinopathic laminitis is common and can be associated with an underlying endocrinopathy, such as equine metabolic syndrome (EMS), pituitary pars intermedia dysfunction (PPID), pasture consumption, or any combination of these factors.
objectivesThe aim of the study was to improve the risk assessment capabilities of clinicians, and to inform management strategies, for acute endocrinopathic laminitis by prospectively examining the phenotypic, hormonal, and clinical characteristics of the disease in a large cohort. ANIMALS: Privately owned horses and ponies (n = 301) of any age, sex, or breed diagnosed with laminitis by a veterinarian. A history of laminitis was acceptable.
methodsThis was a prospective cohort study. Veterinarians provided information on each case via an online questionnaire after informed consent from the animal's owner, and all data were de-identified before analysis. Serum insulin and plasma adrenocorticotrophic hormone concentrations were measured in each case.
resultsMost cases were recruited in spring (109/301; 36.2%). Concurrent EMS and PPID resulted in higher basal insulin concentrations (49 [21.5-141]; P < .02) than if an animal had a single underlying cause for their laminitis. The insulin concentration was negatively correlated (r CONCLUSIONS AND CLINICAL IMPORTANCE: Horses and ponies with concurrent endocrinopathies have more marked hyperinsulinemia. Higher basal insulin concentrations were associated with more severe lameness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.