ArticleEnvironmental science and pollution research international2019
Protective effects of quercetin supplementation against short-term toxicity of cadmium-induced hematological impairment, hypothyroidism, and testicular disturbances in albino rats.
Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review.Current molecular medicine · 2025Pooled it
- Protective effect ofOpen veterinary journal · 2026Article
- Carob extract restores testicular function and sperm quality in cadmium-exposed mice: An experimental study.International journal of reproductive biomedicine · 2025Article
- Mechanisms of a Patented Chinese Herbal Medicine for Treating Hypothyroidism inCurrent pharmaceutical design · 2025Article
- Prospective role of lusianthridin in attenuating cadmium-induced functional and cellular damage in rat thyroid.Heliyon · 2024Article
- Antioxidant and genoprotective effects of osthole against cadmium-induced DNA damage: anResearch in pharmaceutical sciences · 2022Article
- Quercetin Protects Human Thyroid Cells against Cadmium Toxicity.International journal of molecular sciences · 2021Article
- Metabolomics analysis of the effects of quercetin on renal toxicity induced by cadmium exposure in rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- Antioxidant Potential of Parsley Leaf (BioMed research international · 2021Article
- Protective effect of quercetin on rat testes against cadmium toxicity by alleviating oxidative stress and autophagy.Environmental science and pollution research international · 2020Article
- Protective Effects of Myo-Inositol and Selenium on Cadmium-Induced Thyroid Toxicity in Mice.Nutrients · 2020Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
Abstract
The aim of this study was to evaluate the probable protective effect of quercetin (QUE) against cadmium (Cd)-induced sub-chronic toxicity in rats. Adult male rats were given either Cd (as cadmium chloride; 5 mg/kg) alone or in combination with QUE (50 mg/kg) daily for 4 weeks by oral gavage. At the end of the experimental period, Cd accumulation, and selected hematological, thyroid, and reproductive markers were assessed. Results revealed that Cd treatment significantly increased Cd concentrations in blood, thyroid gland, and testicular tissue of rats. Cd also caused a decline in hemoglobin content, hematocrit value, and total erythrocyte and leucocyte counts. Further, significant suppressions in the blood levels of hormones related to thyroid gland function, and male reproductive hormones (i.e., testosterone, luteinizing hormone and follicle-stimulating hormone), were observed in Cd-treated rats compared to the control. In parallel, low sperm count and sperm motility, increased sperm abnormalities, and marked pathology occurred in testis. Combination with QUE recorded amelioration of the deleterious effects of Cd, involving regulation of hematological toxicity and thyroid hormonal levels and subsequently modulation of testicular function. In conclusion, it appears that dietary QUE can rescue from Cd-induced hematological dysfunctions and testicular damage by reversing the hypothyroid state.
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