ArticleJournal of the Endocrine Society2019
The Pituitary Is a Candidate Organ That Modulates Circulating Klotho Levels.
Article in Journal of the Endocrine Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Involvement of α-klotho in growth hormone (GH) signaling.Journal of clinical biochemistry and nutrition · 2024Article
- α-Klotho levels in girls with central precocious puberty: potential as a diagnostic and monitoring marker.Frontiers in endocrinology · 2024Article
- Article
- Gender-specific soluble α-klotho levels as marker of GH deficiency in children: a case-control study.Journal of endocrinological investigation · 2022Article
- Post-kidney transplant soluble Klotho levels are determined by pretransplant soluble Klotho levels in both living donors and recipients.Clinical and experimental nephrology · 2021Observational
- The Complex World of Regulation of Pituitary Growth Hormone Secretion: The Role of Ghrelin, Klotho, and Nesfatins in It.Frontiers in endocrinology · 2021Review
- Changes in Fibroblast Growth Factor 23 and Soluble Klotho Levels After Hemodialysis Initiation.Kidney medicineArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextThe antiaging protein Klotho is shed and released into the blood stream (soluble Klotho). Growth hormone (GH) is considered an active Klotho regulator, because growth retardation is described in Klotho-deficient mice. The origin of circulating Klotho is, however, not fully understood.
objectivesOur objective was to analyze a possible role of the pituitary in regulating soluble Klotho in patients with pituitary adenomas. PATIENTS DESIGN AND
settingWe analyzed serum levels of soluble Klotho, GH, and insulin-like growth factor 1 (IGF-1) from 21 consecutive patients in our center with pituitary tumor, 7 with GH-producing adenomas (GHomas), and 14 with non-GH-producing pituitary adenomas (non-GHomas), before and after endoscopic transsphenoidal surgery (eTSS).
main outcome measureSoluble Klotho levels were determined by ELISA with antihuman Klotho antibodies.
resultsBaseline soluble Klotho levels in all patients, those with GHoma and those with non-GHoma, were 542 (median) (interquartile range: 403, 652), 1083 (425, 1213), and 525 (399, 590), respectively. A drastic reduction in Klotho levels was identified in those with GHoma, accompanied by decreases in GH and IGF-1 levels, after eTSS. Interestingly, patients with non-GHoma had significant declines in soluble Klotho without any significant changes in GH levels. Moreover, an oral glucose tolerance test revealed that soluble Klotho levels decreased, whereas a paradoxical GH peak was observed after glucose intake in a patient with GHoma.
conclusionsOur data suggest that the pituitary may be a key organ that regulates circulating Klotho concentrations, implying that the pituitary possibly controls circulating Klotho through GH-dependent and/or GH-independent mechanisms.
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