Evidence map›Paper›PMID 30697579›Full record

ArticleAmerican journal of clinical and experimental urology2018

Concurrent EAF2 and ELL2 loss phenocopies individual EAF2 or ELL2 loss in prostate cancer cells and murine prostate.

Mingming Zhong, Laura E Pascal, Erdong Cheng, Khalid Z Masoodi, Wei Chen, Anthony Green, Brian W Cross, Erica Parrinello, Lora H Rigatti, Zhou Wang

Open access · greenAbstract read
In one paragraph

Article in American journal of clinical and experimental urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Mingming ZhongDepartment of Urology, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Laura E PascalDepartment of Urology, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Erdong ChengDepartment of Urology, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Khalid Z MasoodiDepartment of Urology, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Wei ChenDepartment of Urology, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Anthony GreenDepartment of Pathology, Pitt Biospecimen Core, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Brian W CrossDepartment of Urology, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Erica ParrinelloDepartment of Urology, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Lora H RigattiDivision of Laboratory Animal Resources, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
Zhou WangUniversity of Pittsburgh Cancer Institute, School of Medicine, University of Pittsburgh Pittsburgh, PA, USA.
University of Pittsburgh · USSher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir · IN

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHN C. BYRD · 1988 to 2026
$158.0M
Targeting FOXA1-downstream pathways: a novel therapeutic strategy for castration-resistant prostate cancerP50CA180995 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ABDULKADIR, SARKI A., HUSSAIN, MAHA H · 2015 to 2025
$19.9M
Urologic Training Program for Physicians and ScientistsT32DK007774 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, ZHOU · 1999 to 2014
$2.3M
Roles of EAF2 in androgen action in the prostateR01CA186780 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, ZHOU · 2014 to 2018
$1.9M
Cellular mechanisms of androgen action and androgen-response gene EAF2 in prostate cancerR50CA211242 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PASCAL, LAURA ELLEN · 2016 to 2020
$575k
NCI NIH HHS P30 CA047904NCI NIH HHS P50 CA180995NCI NIH HHS R01 CA186780NCI NIH HHS R50 CA211242NIDDK NIH HHS T32 DK007774
6 · The paper itself

Abstract

Elongation factor for RNA polymerase II 2 (ELL2) and ELL-associated factor 2 (EAF2) are two functionally related androgen responsive gene-encoded proteins with prostate tumor suppressor characteristics. EAF2 and ELL2 have both been shown to be down-regulated in advanced prostate cancer, and mice with either

Indexed as

22Rv1C4-2EAF2ELL2mouseprostate cancer

Identifiers

PMID30697579
PMCPMC6334201
OpenAlexW2980804587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.