ArticleOpen forum infectious diseases2019
The Italian 2017 Outbreak Chikungunya Virus Belongs to an Emerging
Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chikungunya fever in Africa: a systematic review.Pathogens and global health · 2020Pooled it
- Behavioral heterogeneity in host seeking and post-feeding suppression among disease vector mosquitoes.Communications biology · 2026Article
- Chikungunya resurgence in Italy: a signal of vectorborne viruses changing pattern in the era of climate change?Frontiers in public health · 2026Article
- Phylogenetic Analysis of Chikungunya Virus Eastern/Central/South African-Indian Ocean Epidemic Strains, 2004-2019.Viruses · 2025Article
- Observational
- Temperature and photoperiod differentially impact maternal phenotypes in diapause egg-laying Aedes albopictus mosquitoes.PLoS neglected tropical diseases · 2024Article
- Barcoding of Italian mosquitoes (BITMO): generation and validation of DNA barcoding reference libraries for native and alien species of Culicidae.Parasites & vectors · 2024Article
- The evolutionary and molecular history of a chikungunya virus outbreak lineage.PLoS neglected tropical diseases · 2024Article
- A DNA barcode reference library of Croatian mosquitoes (Diptera: Culicidae): implications for identification and delimitation of species, with notes on the distribution of potential vector species.Parasites & vectors · 2024Article
- Assessing the Risk of Dengue Virus Local Transmission: Study on Vector Competence of ItalianViruses · 2024Article
- Epidemiology and Economic Burden of Chikungunya: A Systematic Literature Review.Tropical medicine and infectious disease · 2023Review
- Article
- Climate Change and Travel: Harmonizing to Abate Impact.Current infectious disease reports · 2023Review
- Article
- Estimating chikungunya virus transmission parameters and vector control effectiveness highlights key factors to mitigate arboviral disease outbreaks.PLoS neglected tropical diseases · 2022Article
- Dengue Fever in Italy: The "Eternal Return" of an Emerging Arboviral Disease.Tropical medicine and infectious disease · 2022Review
- Maternally Instigated Diapause inFrontiers in behavioral neuroscience · 2022Review
- Natural-Product-Based Solutions for Tropical Infectious Diseases.Clinical microbiology reviews · 2021Review
- Chikungunya virus infection: molecular biology, clinical characteristics, and epidemiology in Asian countries.Journal of biomedical science · 2021Review
- Examining Wing Length-Abundance Relationships and Pyrethroid Resistance Mutations amongInternational journal of environmental research and public health · 2021Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChikungunya virus is an emerging mosquito-borne pathogen with a wide global distribution. With the severe morbidity that it causes, chikungunya virus is a major public health problem in the affected areas and poses a considerable risk for unaffected areas hosting competent vector populations. In the summer of 2017, Italy experienced a chikungunya virus outbreak that spread in the Lazio region and caused a secondary outbreak in the Calabrian village of Guardavalle, with a final case number of 436. The causative strain was recognized as an Indian Ocean lineage (IOL) virus.
methodsTo understand the underlying genetic and molecular features of the outbreak virus, viruses from mosquito pools and clinical samples were isolated in cell culture and subjected to whole-genome sequencing and genetic analyses.
resultsAll 8 characterized genomes shared a high sequence identity. A distinct substitution pattern in the Italian 2017 viruses (including mutations in E1, E2, and nsP4) was partly shared with the Pakistani 2016 outbreak viruses. Evolutionary analyses indicate that these 2 recent outbreaks and several geographically widely distributed, travel-associated viruses form a cluster of rapidly emerging Indian-origin IOL viruses.
conclusionsOur analyses show that the 2017 Italian outbreak virus belongs to a cluster of novel IOL chikungunya viruses originating in India. Their emergence calls for enhanced monitoring and strengthened preparedness measures, including vector control programs and raised awareness among general practitioners in countries potentially at risk.
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