ArticleAmerican journal of clinical and experimental immunology2018
Serum levels of histamine and diamine oxidase in multiple sclerosis.
Article in American journal of clinical and experimental immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 32 citations in OpenAlex.
- Prediction of Post-Infectious Inflammatory Response Syndrome in Patients with Cryptococcal Meningitis Based on Clinical and Radiomics Data.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- In Silico Analysis Highlights Potential Predictive Indicators Associated with Secondary Progressive Multiple Sclerosis.International journal of molecular sciences · 2024Article
- Effect of Silybum Marianum on Reduction of Chemotherapy-Induced Peripheral Neurotoxicity with Cisplatin.Advanced biomedical research · 2024Article
- Histamine and Serotonin Levels in Bone Marrow Stem Cells Niche as Potential Biomarkers of Systemic Mastocytosis and Myeloproliferative Disorders.Stem cell reviews and reports · 2023Article
- Evaluation of the Relative Frequency of Epstein-Barr Virus Infection in Patients with Recurrent Breast Cancer Compared with Patients with Nonrecurrent Breast Cancer.Advanced biomedical research · 2023Article
- Neuronal activity and remyelination: new insights into the molecular mechanisms and therapeutic advancements.Frontiers in cell and developmental biology · 2023Review
- Evaluation of sleep quality in faculty members of Isfahan university of medical sciences.International journal of physiology, pathophysiology and pharmacology · 2023Article
- The role of 18F-fluorodeoxyglucose PET/computed tomography in the diagnosis and monitoring of large vessel vasculitides - a review article.American journal of nuclear medicine and molecular imaging · 2023Review
- A rare case of hypomelanosis of Ito with enlargement of Virchow-Rabin spaces in a 10-year-old child with symptoms of seizures.American journal of neurodegenerative disease · 2023Article
- The feasibility of PETHEMA ALL-96 regimen on treatment of patients with acute lymphoid leukemia.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Article
- Platelet-rich plasma therapy or arthroscopic surgery on repair of anterior cruciate ligament rupture.European journal of translational myology · 2022Article
- Repurposing Histaminergic Drugs in Multiple Sclerosis.International journal of molecular sciences · 2022Article
- Evaluation of the serum level of osteoprotegerin and bone mineral density in postmenopausal women.International journal of physiology, pathophysiology and pharmacology · 2022Article
- Evaluation of patterns, cause and risk factors of burns in patients with seizure.International journal of burns and trauma · 2022Article
- The Histamine and Multiple Sclerosis Alliance: Pleiotropic Actions and Functional Validation.Current topics in behavioral neurosciences · 2022Article
- Contrast-enhanced weighted-T1 and FLAIR sequences in MRI of meningeal lesions.American journal of nuclear medicine and molecular imaging · 2022Article
- Comparing the Effectiveness of Bupivacaine Administration through Chest Tube and Intercostal Blockage in Patients with Rib Fractures.Advanced biomedical research · 2022Article
- The roles of dipeptidyl peptidase-4 inhibitors in prognosis of COVID-19 infection in patients with type 2 diabetes mellitus.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2022Article
- Predictive value of number and volume of demyelinating plaques in treatment response in patients with multiple sclerosis treated with INF-B.American journal of neurodegenerative disease · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMultiple Sclerosis (MS) is an autoimmune disease of the central nervous system, mostly affecting young adults. Diamine oxidase is an enzyme essential for histamine production. Histamine which is produced mostly by mast cells can have effects on different aspects of immune system via its different histamine receptors (H1R, H2R, H3R and H4R). The crucial role of diamine oxidase and histamine in immune balance has been documented in different studies and experiments both on MS patients and on experimental allergic encephalomyelitis (EAE). In this regard, we aimed to measure the level of histamine and diamine oxidase in the serum of MS patients.
methodsA total number of 50 relapsing-remitting MS (RRMS) patients and 41 age and sex matched controls were enrolled in this study. Assessments of serum levels of histamine and diamine oxidase enzyme were performed using enzyme-linked immune sorbent assay (ELISA).
resultsThe serum levels of histamine and diamine oxidase in RRMS patients were lower than healthy controls (
conclusionOur research team found significant low levels of histamine and diamine oxidase in RRMS patients; however the pathogenesis of this issue was unclear.
Indexed as
Identifiers
30697467PMC6334194W2990894375What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.