Evidence map›Paper›PMID 30697465›Full record

ArticleTranslational vision science & technology2019

Proteomic Profiles in Advanced Age-Related Macular Degeneration Using an Aptamer-Based Proteomic Technology.

Anne M Lynch, Brandie D Wagner, Sophie J Weiss, Kirsten M Wall, Alan G Palestine, Marc T Mathias, Frank S Siringo, Jennifer N Cathcart, Jennifer L Patnaik, Daniel W Drolet and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Anne M LynchDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Brandie D WagnerDepartment of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
Sophie J WeissSomaLogic, Inc., Boulder, CO, USA.
Kirsten M WallSomaLogic, Inc., Boulder, CO, USA.
Alan G PalestineDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Marc T MathiasDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Frank S SiringoDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Jennifer N CathcartDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Jennifer L PatnaikDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
Daniel W DroletSomaLogic, Inc., Boulder, CO, USA.
Nebojsa JanjicSomaLogic, Inc., Boulder, CO, USA.
Naresh MandavaDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.
University of Colorado Denver · USSomaLogic (United States) · USColorado School of Public Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo explore top-ranked plasma proteins related to neovascular age-related macular degeneration (AMD) and geographic atrophy (GA), and explore pathways related to neovascular AMD and GA.

methodsWe conducted a pilot study of patients with neovascular AMD (

resultsIn this pilot study

conclusionsWe found different proteins and different pathways associated with neovascular AMD and GA. Vinculin and some of the top-ranked pathways have been previously associated with AMD, whereas others have not been described. TRANSLATIONAL RELEVANCE: Biomarkers identified in plasma likely reflect systemic alterations in protein expression and may improve our understanding of the mechanisms leading to AMD.

Indexed as

aptamer-based technologiesgeographic atrophyneovascular AMDproteomics

Identifiers

PMID30697465
PMCPMC6348995
OpenAlexW2912434499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.