Evidence map›Paper›PMID 30697266›Full record

ArticleArchives of medical science : AMS2019

Renin-angiotensin system inhibitor attenuates oxidative stress induced human coronary artery endothelial cell dysfunction via the PI3K/AKT/mTOR pathway.

Xuekun Shi, Yuhua Guan, Shaoyan Jiang, Tiandong Li, Bing Sun, Huan Cheng

Open access · goldAbstract read
In one paragraph

Article in Archives of medical science : AMS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Protective potential of curcumin in L-NAME-induced hypertensive rat model: AT1R, mitochondrial DNA synergy.International journal of physiology, pathophysiology and pharmacology · 2020
    Article
  15. Saturated hydrogen alleviates CClThe Journal of international medical research · 2020
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xuekun ShiDepartment of Cardiovasology, the Affiliated Cardiovascular Hospital of Qindao University, Qindao, Shaodong, China.
Yuhua GuanDepartment of Neurology, the BaZhou People's Hospital of XinJiang Uygur Autonomous Region, XinJiang Uygur Autonomous Region, China.
Shaoyan JiangDepartment of Cardiovasology, the Affiliated Cardiovascular Hospital of Qindao University, Qindao, Shaodong, China.
Tiandong LiDepartment of Cardiovasology, the Affiliated Cardiovascular Hospital of Qindao University, Qindao, Shaodong, China.
Bing SunDepartment of Cardiovasology, the Affiliated Cardiovascular Hospital of Qindao University, Qindao, Shaodong, China.
Huan ChengDepartment of Neurology, the BaZhou People's Hospital of XinJiang Uygur Autonomous Region, XinJiang Uygur Autonomous Region, China.
Affiliated Hospital of Qingdao University · CNPeople's Hospital of Xinjiang Uygur Autonomous Region · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe renin-angiotensin system is associated with blood pressure regulation, inflammation, oxidative stress and insulin resistance. It can decrease intracellular oxidative stress. Stimulation with H MATERIAL AND

methodsHuman coronary artery endothelial cells (HCAECs) were used. The cells were treated with H

resultsThe renin-angiotensin system inhibitor captopril reversed H

conclusionsThe study revealed the protective effect of captopril against H

Indexed as

AKT/mTOR pathwayapoptosisendothelial cell dysfunctionoxidative stressrenin-angiotensin system inhibitor

Identifiers

PMID30697266
PMCPMC6348342
OpenAlexW2790212646

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.