ArticleFrontiers in physiology2018
Investigating Gut Permeability in Animal Models of Disease.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
- The Future of Protozoan Infection Research: 3D Cell Culture and beyond.ACS infectious diseases · 2026Review
- The Intestinal Barrier: A Multilayered Gatekeeper Against Systemic Disease.International journal of microbiology · 2026Review
- Gut feelings and sweet teeth: nutritional solutions to the gut damage in inflammatory bowel disease and HIV infection.Frontiers in nutrition · 2026Review
- Article
- Multi-omics reveals different signatures of obesity-prone and obesity-resistant mice.iMetaOmics · 2025Article
- The effects of induced hindgut acidosis in sheep on rumen fermentation and gut permeability.Journal of animal science · 2025Article
- Special delivery - extracellular vesicles released by commensal gut bacteria deliver bioactive protein to distal organs.Extracellular vesicles and circulating nucleic acids · 2025Article
- Host resources and parasite traits interact to determine the optimal combination of host parasite-mitigation strategies.Ecology and evolution · 2024Article
- Gender-affirming hormone therapy preserves skeletal maturation in young mice via the gut microbiome.The Journal of clinical investigation · 2024Article
- Alkaline sphingomyelinase deficiency impairs intestinal mucosal barrier integrity and reduces antioxidant capacity in dextran sulfate sodium-induced colitis.World journal of gastroenterology · 2024Article
- Utilizing the apical-out enteroidsFrontiers in physiology · 2024Article
- AnFrontiers in immunology · 2024Article
- Article
- Microbial Interventions to Improve Neonatal Gut Health.Microorganisms · 2023Review
- Callus γδ T cells and microbe-induced intestinal Th17 cells improve fracture healing in mice.The Journal of clinical investigation · 2023Article
- Article
- Highly Sensitive, Flow Cytometry-Based Measurement of Intestinal Permeability in Models of Experimental Colitis.Cellular and molecular gastroenterology and hepatology · 2023Article
- Supplementation with postbiotic fromFrontiers in microbiology · 2023Article
- Redox and Metabolic Regulation of Intestinal Barrier Function and Associated Disorders.International journal of molecular sciences · 2022Review
- Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.Microbiome · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing number of investigations report the association between gut permeability and intestinal or extra-intestinal disorders under the basis that translocation of gut luminal contents could affect tissue function, either directly or indirectly. Still, in many cases it is unknown whether disruption of the gut barrier is a causative agent or a consequence of these conditions. Adequate experimental models are therefore required to further understand the pathophysiology of health disorders associated to gut barrier disruption and to develop and test pharmacological treatments. Here, we review the current animal models that display enhanced intestinal permeability, and discuss (1) their suitability to address mechanistic questions, such as the association between gut barrier alterations and disease and (2) their validity to test potential treatments for pathologies that are characterized by enhanced intestinal permeability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.