Evidence map›Paper›PMID 30696948›Full record

ReviewLeukemia2019

European recommendations and quality assurance for cytogenomic analysis of haematological neoplasms.

K A Rack, E van den Berg, C Haferlach, H B Beverloo, D Costa, B Espinet, N Foot, S Jeffries, K Martin, S O'Connor and 6 more

Abstract readReview
In one paragraph

Review in Leukemia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. Article
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  3. Review
  4. Article
  5. Article
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  11. Article
  12. Chromoanagenesis in Multiple Myeloma: A Comprehensive Overview.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  13. Review
  14. Review
  15. Article
  16. Article
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  18. Article
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

K A RackGenQA, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK.
E van den BergDepartment of Genetics University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
C HaferlachMLL-Munich Leukemia Laboratory, Munich, Germany.
H B BeverlooDepartment of Clinical Genetics, Erasmus MC, University medical center, Rotterdam, The Netherlands.
D CostaHematopathology Section, Hospital Clinic, Barcelona, Spain.
B EspinetLaboratori de Citogenètica Molecular, Servei de Patologia, Grup de Recerca,Translacional en Neoplàsies Hematològiques, Cancer Research Program, imim-Hospital del Mar, Barcelona, Spain.
N FootViapath Genetics laboratories, Guys Hospital, London, UK.
S JeffriesWest Midlands Regional Genetics Laboratory, Birmingham Women's Hospital, Birmingham, UK.
K MartinDepartment of Cytogenetics, Nottingham University Hospital, Nottingham, UK.
S O'ConnorHaematological Malignancy Diagnostic Service, St James's University Hospital, Leeds, UK.
J SchoumansOncogénomique laboratory, Hematology department, Lausanne University Hospital, Vaudois, Switzerland.
P TalleyHaematological Malignancy Diagnostic Service, St James's University Hospital, Leeds, UK.
N TelfordOncology Cytogenetics Service, The Christie NHS Foundation Trust, Manchester, UK.
S StiouiLaboratorio di Citogenetica e genetica moleculaire, Laboratorio Analisi, Humanitas Research Hospital, Rozzano, Milan, Italy.
Z ZemanovaPrague Center of Oncocytogenetics, Institute of Clinical Biochemistry and Laboratory Diagnostics, General University Hospital and First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
R J HastingsGenQA, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK. Ros.Hastings@ouh.nhs.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytogenomic investigations of haematological neoplasms, including chromosome banding analysis, fluorescence in situ hybridisation (FISH) and microarray analyses have become increasingly important in the clinical management of patients with haematological neoplasms. The widespread implementation of these techniques in genetic diagnostics has highlighted the need for guidance on the essential criteria to follow when providing cytogenomic testing, regardless of choice of methodology. These recommendations provide an updated, practical and easily available document that will assist laboratories in the choice of testing and methodology enabling them to operate within acceptable standards and maintain a quality service.

Indexed as

Chromosome BandingHematologic NeoplasmsHumansIn Situ Hybridization, FluorescenceLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Myeloid, AcuteLymphomaMicroarray AnalysisMultiple MyelomaMyelodysplastic Syndromes

Identifiers

PMID30696948
PMCPMC6756035

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.