SynthesisSpinal cord2019
Effect of electrical stimulation on muscle atrophy and spasticity in patients with spinal cord injury - a systematic review with meta-analysis.
Synthesis in Spinal cord, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Non-invasive cerebral and spinal cord stimulation for motor and gait recovery in incomplete spinal cord injury: systematic review and meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Effects of Bed Rest on Physical Performance in Athletes: A Systematic and Narrative Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Efficacy of aquatic therapy in people with spinal cord injury: a systematic review and meta-analysis.Spinal cord · 2023Pooled it
- Physiotherapy interventions for the treatment of spasticity in people with spinal cord injury: a systematic review.Spinal cord · 2021Pooled it
- Handcycling with concurrent lower body low-frequency electromyostimulation significantly increases acute oxygen uptake in elite wheelchair basketball players: an acute crossover trial.Journal of rehabilitation medicine · 2024Trial
- Merging neural stimulation and exoskeletons to enhance sensorimotor hand functions after brain or spinal cord injury.Science advances · 2026Article
- An Endogenous Proton-Powered Adaptive Nanomotor for Treating Muscle Atrophy.Materials (Basel, Switzerland) · 2025Article
- Perspectives on Barriers to Use and Benefits of Functional Electrical Stimulation From Australians and New Zealanders With SCI and Clinicians and Researchers in the Field.Topics in spinal cord injury rehabilitation · 2025Article
- Galactin-3 regulation of CDC42 promotes neuronal autophagy following spinal cord injury.Frontiers in cellular neuroscience · 2025Article
- Sciatic Nerve Electrical Stimulation Enhances Locomotor Recovery in Rats Following Spinal Cord Contusion.Neuroscience insights · 2025Article
- Impact of electrical muscle stimulation-induced muscle contractions on endogenous pain modulatory system: a quantitative sensory testing evaluation.BMC musculoskeletal disorders · 2024Article
- A Miniaturized Wireless, Battery-free Implant for In Vivo Musculoskeletal Stimulation.The ... Midwest Symposium on Circuits and Systems conference proceedings : MWSCAS. Midwest Symposium on Circuits and Systems · 2024Article
- Electrical Stimulation Prevents Muscular Atrophy and the Decrease of Interleukin-6 in Paralyzed Muscles after Spinal Cord Injury in Rats.Revista brasileira de ortopedia · 2024Article
- Analysis of gene expression in microglial apoptotic cell clearance following spinal cord injury based on machine learning algorithms.Experimental and therapeutic medicine · 2024Article
- Effects of Neuromuscular Electrical Stimulation for Quadriceps Muscle Thickness and Lower Extremity Motor Score in Individuals with Subacute Incomplete Cervical Spinal Cord Injury: A Randomized Controlled Trial.Physical therapy research · 2024Article
- The effect of electromyographic feedback functional electrical stimulation on the plantar pressure in stroke patients with foot drop.Frontiers in neuroscience · 2024Article
- Neuromuscular disorders in women and men with spinal cord injury are associated with changes in muscle and tendon architecture.The journal of spinal cord medicine · 2023Article
- Cortical activation of neuromuscular electrical stimulation synchronized mirror neuron rehabilitation strategies: an fNIRS study.Frontiers in neurology · 2023Article
- Epidural oscillating field stimulation increases axonal regenerative capacity and myelination after spinal cord trauma.Neural regeneration research · 2022Article
- Identification of hub genes in the subacute spinal cord injury in rats.BMC neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designThis work is a systematic review with meta-analysis
objectiveEvaluate the effect of electrical stimulation (ES) on skeletal muscle volume and spasticity in individuals with spinal cord injury (SCI).
settingUniversity of Brasilia, Brazil
methodsSearches were conducted of the Cochrane Library, MEDLINE, CINAHL, PEDro, PsycINFO and EMBASE electronic databases for relevant articles published up to June 2018. No restrictions were imposed regarding the year of publication. The inclusion criteria were randomized controlled trials involving adults with SCI comparing ES to an active or passive control. Two independent reviewers extracted the data from the selected studies and methodological quality was assessed using the PEDro scale.
resultsThe initial search led to the retrieval of 164 studies, seven of which met the eligibility criteria, but only six were included in the meta-analysis. The six studies comprised 104 patients with complete or incomplete SCI. In the two studies that investigated the use of ES on muscle volume of the lower limbs, the overall effect was statistically significant in patients with acute SCI (mean difference: 0.86; 95% CI: 0.04 to 1.69; p < 0.04). Among the four studies that examined the use of ES for spasticity of the lower limb, the overall effect was non-significant (mean difference: 0.55; 95% CI: -0.31 to 1.41; p = 0.21).
conclusionsElectrical stimulation was found to be an effective method for increasing muscle volume in SCI patients, but had no effect on spasticity. Further investigation of the effect of ES on spasticity in SCI is needed.
Indexed as
Identifiers
30696926What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.