ArticleScientific reports2019
Melamine promotes calcium crystal formation in three-dimensional microfluidic device.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Calcium Phosphate-Induced Injury in Kidney Tubular Cells-Supersaturated Solution vs Preformed Crystals.Journal of biochemical and molecular toxicology · 2025Article
- Sex-specific Stone-forming Phenotype in Mice During Hypercalciuria/Urine Alkalinization.Laboratory investigation; a journal of technical methods and pathology · 2024Article
- Ablation of TRPC3 disrupts CaScientific reports · 2023Article
- TRPC Channels in the Physiology and Pathophysiology of the Renal Tubular System: What Do We Know?International journal of molecular sciences · 2022Review
- Hypercalciuria switches CaGenes & diseases · 2022Article
- Differential biomolecular recognition by syntheticJournal of materials chemistry. B · 2021Article
- Tannic acid attenuates vascular calcification-induced proximal tubular cells damage through paracrine signaling.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Article
- Modulation of Tubular pH by Acetazolamide in a CaInternational journal of molecular sciences · 2021Article
- Theaflavin protects against oxalate calcium-induced kidney oxidative stress injury via upregulation of SIRT1.International journal of biological sciences · 2021Article
- l-ornithine activates CaCellular signalling · 2020Article
- Matting Calcium Crystals by Melamine Improves Stabilization and Prevents Dissolution.Crystal growth & design · 2019Article
- Abrogation of store-operated CaCell death discovery · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Melamine, which induces proximal tubular (PT) cell damage has a greater nephrotoxic effect when combined with cyanuric and uric acids; however, it is unknown whether such effect can stimulate calcium phosphate (CaP)/calcium oxalate (CaOx) stone formation. Here, we show that melamine acts as an inducer of CaP, CaOx and CaP + CaOx (mixed) crystal formations in a time and concentration-dependent manner by stabilizing those crystals and further co-aggregating with melamine. To explore the physiological relevance of such melamine-augmented calcium crystal formation, we used 2-dimensional (2D) and 3D microfluidic (MF) device, embedded with PT cells, which also resembled the effect of melamine-stimulated CaP, CaOx and mixed crystal formation. Significantly, addition of preformed CaP and/or CaOx crystal in the presence of melamine, further potentiated those crystal formations in 3D MFs, which helped the growth and aggregation of mixed crystals. Our data show that the mechanism of such predisposition of stone formation could be largely due to co-crystallization between melamine and CaP/CaOx and pronounced effect on induction of stone-forming pathway activation in 3D MF. Taken together, melamine-induced CaP and/or CaOx crystal formation ex-vivo will help us in understanding the larger role of melamine as an environmental toxicant in producing the pathology in similar cellular microenvironments.
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Registered trials
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