ArticleScientific reports2019
Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Timing Is Everything: The Effect of Exposure to Pollution on Wildlife Gut Microbiota Is Contingent on Season.Molecular ecology · 2026Article
- No Evidence That Life History Strategies Shape Within-Body Mosaics of Ageing.Molecular ecology · 2025Article
- A novel carnivorous diet reduces brain telomere length.Biology letters · 2025Article
- Stratification of telomerase activity in cancer reveals associations with senescence and genomic instability.Computational and structural biotechnology journal · 2025Article
- The role of Poly-ADP ribose polymerase (PARP) enzymes in chemotherapy-induced cognitive impairments - parallels with other neurodegenerative disorders.Frontiers in pharmacology · 2025Review
- Ionizing radiation has negligible effects on the age, telomere length and corticosterone levels of Chornobyl tree frogs.Biology letters · 2024Article
- The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics.npj biodiversity · 2024Article
- BIBR1532 combined with radiotherapy induces ferroptosis in NSCLC cells and activates cGAS-STING pathway to promote anti-tumor immunity.Journal of translational medicine · 2024Article
- Immune aging: biological mechanisms, clinical symptoms, and management in lung transplant recipients.Frontiers in transplantation · 2024Review
- Telomere length predicts timing and intensity of migratory behaviour in a nomadic songbird.Biology letters · 2022Article
- Interpretation of gut microbiota data in the 'eye of the beholder': A commentary and re-evaluation of data from 'Impacts of radiation exposure on the bacterial and fungal microbiome of small mammals in the Chernobyl Exclusion Zone'.The Journal of animal ecology · 2022Article
- Telomere dynamics in female Columbian ground squirrels: recovery after emergence and loss after reproduction.Oecologia · 2022Article
- A multi-tissue view on telomere dynamics and postnatal growth.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2022Article
- Cabazitaxel suppresses the proliferation and promotes the apoptosis and radiosensitivity of castration-resistant prostate cancer cells by inhibiting PI3K/AKT pathway.American journal of translational research · 2022Article
- Antiproliferative Effects of Ferulic, Coumaric, and Caffeic Acids in HepG2 Cells byAdvances in pharmacological and pharmaceutical sciences · 2022Article
- Individual quality and phenology mediate the effect of radioactive contamination on body temperature in Chernobyl barn swallows.Ecology and evolution · 2021Article
- Expansion of rDNA and pericentromere satellite repeats in the genomes of bank volesEcology and evolution · 2021Article
- Disproportionate Impacts of Radiation Exposure on Women, Children, and Pregnancy: Taking Back our Narrative.Journal of the history of biology · 2021Article
- Telomeres and Telomere Length: A General Overview.Cancers · 2020Review
- Exploiting σ-hole interaction to design small uncharged ligand molecules to stabilize G-quadruplex-DNA: a computational study.Journal of molecular modeling · 2020Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres, the protective structures at the ends of chromosomes, can be shortened when individuals are exposed to stress. In some species, the enzyme telomerase is expressed in adult somatic tissues, and potentially protects or lengthens telomeres. Telomeres can be damaged by ionizing radiation and oxidative stress, although the effect of chronic exposure to elevated levels of radiation on telomere maintenance is unknown for natural populations. We quantified telomerase expression and telomere length (TL) in different tissues of the bank vole Myodes glareolus, collected from the Chernobyl Exclusion Zone, an environment heterogeneously contaminated with radionuclides, and from uncontaminated control sites elsewhere in Ukraine. Inhabiting the Chernobyl Exclusion Zone was associated with reduced TL in the liver and testis, and upregulation of telomerase in brain and liver. Thus upregulation of telomerase does not appear to associate with longer telomeres but may reflect protective functions other than telomere maintenance or an attempt to maintain shorter telomeres in a stressful environment. Tissue specific differences in the rate of telomere attrition and apparent radiosensitivity weaken the intra-individual correlation in telomere length among tissues in voles exposed to radionuclides. Our data show that ionizing radiation alters telomere homeostasis in wild animal populations in tissue specific ways.
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