Evidence map›Paper›PMID 30696870›Full record

ArticleScientific reports2019

SLIME: robust, high-speed 3D microvascular mapping.

Yehe Liu, Meredith C G Broberg, Michiko Watanabe, Andrew M Rollins, Michael W Jenkins

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yehe LiuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, USA.
Meredith C G BrobergDepartment of Pediatrics, Case Western Reserve University, Cleveland, USA.
Michiko WatanabeDepartment of Pediatrics, Case Western Reserve University, Cleveland, USA.
Andrew M RollinsDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, USA.
Michael W JenkinsDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, USA. mwj5@case.edu.

Funding

Optical Tools to Assess the Role of Hemodynamics in the Development of Congenital Heart DefectsR01HL126747 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JENKINS, MICHAEL W. · 2015 to 2025
$6.4M
OCT Imaging Technology for Developmental Cardiology ResearchR01HL083048 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ROLLINS, ANDREW MARTIN · 2006 to 2016
$3.2M
NHLBI NIH HHS R01 HL083048NHLBI NIH HHS R01 HL126747
6 · The paper itself

Abstract

Three dimensional (3D) microvascular imaging of cubic millimeter to centimeter size volumes often requires much time and expensive instruments. By combining optical clearing with a novel scatter-based optical coherence tomography (OCT) contrast agent, we have greatly extended OCT imaging depth in excised tissues while maintaining a simple and low cost approach that does not require in-depth OCT knowledge. The new method enables fast 3D microvascular mapping in large tissue volumes, providing a promising tool for investigating organ level microvascular abnormalities in large cohorts.

Indexed as

Imaging, Three-DimensionalPhysical Conditioning, AnimalAnimalsContrast MediaDisease Models, AnimalFetal Alcohol Spectrum DisordersMicrovesselsNanoparticlesTomography, Optical CoherenceContrast Media

Identifiers

PMID30696870
PMCPMC6351571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.