Evidence map›Paper›PMID 30696857›Full record

ArticleScientific reports2019

Characterization of sulfur-compound metabolism underlying wax-ester fermentation in Euglena gracilis.

Koji Yamada, Tomoaki Nitta, Kohei Atsuji, Maeka Shiroyama, Komaki Inoue, Chieko Higuchi, Nobuko Nitta, Satoshi Oshiro, Keiichi Mochida, Osamu Iwata and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Enhanced Recovery of Food-GradeMicroorganisms · 2025
    Article
  3. Article
  4. Changes in Sulfur Metabolism in Mouse Brains following Radon Inhalation.International journal of environmental research and public health · 2022
    Article
  5. Review
  6. Article
  7. Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Genetic Engineering Strategies forFrontiers in bioengineering and biotechnology · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Koji Yamadaeuglena Co., Ltd., Tokyo, 108-0014, Japan.
Tomoaki Nittaeuglena Co., Ltd., Tokyo, 108-0014, Japan.
Kohei Atsujieuglena Co., Ltd., Tokyo, 108-0014, Japan.
Maeka ShiroyamaInnovation Medical Research Institute, University of Tsukuba, Ibaraki, 305-8577, Japan.
Komaki InoueCenter for Sustainable Resource Science, RIKEN, Kanagawa, 230-0045, Japan.ORCID 0000-0002-7645-7862
Chieko Higuchieuglena Co., Ltd., Tokyo, 108-0014, Japan.
Nobuko Nittaeuglena Co., Ltd., Tokyo, 108-0014, Japan.
Satoshi OshiroInnovation Medical Research Institute, University of Tsukuba, Ibaraki, 305-8577, Japan.
Keiichi MochidaMicroalgae Production Control Technology Laboratory, RIKEN, Kanagawa, 230-0045, Japan.
Osamu Iwataeuglena Co., Ltd., Tokyo, 108-0014, Japan.
Iwao Ohtsueuglena Co., Ltd., Tokyo, 108-0014, Japan.
Kengo Suzukieuglena Co., Ltd., Tokyo, 108-0014, Japan. suzuki@euglena.jp.
University of Tsukuba · JPKihara Institute for Biological Research · JPRIKEN Center for Sustainable Resource Science · JPSuzuki (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Euglena gracilis is a microalga, which has been used as a model organism for decades. Recent technological advances have enabled mass cultivation of this species for industrial applications such as feedstock in nutritional foods and cosmetics. E. gracilis degrades its storage polysaccharide (paramylon) under hypoxic conditions for energy acquisition by an oxygen-independent process and accumulates high amount of wax-ester as a by-product. Using this sequence of reactions referred to as wax-ester fermentation, E. gracilis is studied for its application in biofuel production. Although the wax-ester production pathway is well characterized, little is known regarding the biochemical reactions underlying the main metabolic route, especially, the existence of an unknown sulfur-compound metabolism implied by the nasty odor generation accompanying the wax-ester fermentation. In this study, we show sulfur-metabolomics of E. gracilis in aerobic and hypoxic conditions, to reveal the biochemical reactions that occur during wax-ester synthesis. Our results helped us in identifying hydrogen sulfide (H

Indexed as

AnaerobiosisBiofuelsEstersEuglena gracilisFermentationGlucansHydrogen SulfideHypoxiaMetabolomicsSignal TransductionSulfur CompoundsWaxesBiofuelsEstersGlucansHydrogen SulfideparamylonSulfur CompoundsWaxes

Identifiers

PMID30696857
PMCPMC6351624
OpenAlexW2913848584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.