ArticleNature communications2019
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 402 papers, 9 of them syntheses that pooled it.
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402citing papers in PubMed, 9 pooled it
33.8field-weighted citation impact, top 1% of its field
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Who cites it
402 citing papers in PubMed, 9 syntheses or guidelines pooled it, 708 citations in OpenAlex.
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- Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk.Nature genetics · 2026Pooled it
- Chronotype differences in the risk of cancers, diabetes mellitus, and poor mental health among shift workers: a meta-analysis.Scandinavian journal of work, environment & health · 2026Pooled it
- Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.Atherosclerosis · 2026Pooled it
- Assessment of bidirectional relationships between sleep traits and frailty: A bidirectional Mendelian randomization study.Medicine · 2025Pooled it
- Food Intake According to Clock Gene Polymorphisms: A Systematic Review.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Pooled it
- Associations between sleep traits and colorectal cancer: a mendelian randomization analysis.Frontiers in oncology · 2025Pooled it
- Genetic estimation of causalities between educational attainment with common digestive tract diseases and the mediating pathways.BMC gastroenterology · 2024Pooled it
- Circadian Variation in the Response to Vaccination: A Systematic Review and Evidence Appraisal.Journal of biological rhythms · 2024Pooled it
- Association between circadian rhythm-related behaviors and breast cancer: a bidirectional Mendelian randomization study.Future science OA · 2026Article
- Plasma proteomics of sleep traits reveals systemic immune-metabolic pathways and genetically prioritized proteins.Molecular psychiatry · 2026Article
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- Emerging genetics of sleep and circadian disorders.Current opinion in pediatrics · 2026Article
- Social jet lag is associated with incident cardiovascular disease independent of sleep duration and cardiac genetic risk.Journal of internal medicine · 2026Article
- Dissecting the shared genetic architecture and biological mechanisms linking sleep traits and suicide attempts: from variants to genes.Molecular psychiatry · 2026Article
- Longitudinal digital phenotyping of activity rhythms and biological aging using commercial wearables.Nature communications · 2026Article
- Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness.Molecular psychiatry · 2026Article
- Genetic evidence for the associations of sleep patterns with cognitive function in older adults: insights from polygenic scores in the Taiwan biobank.European archives of psychiatry and clinical neuroscience · 2026Article
342 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors at 13 institutions in 5 countries.
Samuel E JonesGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-0153-922X
Jacqueline M LaneCenter for Genomic Medicine, Massachusetts General Hospital, Boston, 02114, MA, USA.
Andrew R WoodGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
Vincent T van HeesNetherlands eScience Center, Amsterdam, 1098, XG, Netherlands.ORCID http://orcid.org/0000-0003-0182-9008
Jessica TyrrellGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
Robin N BeaumontGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-0750-8248
Aaron R JeffriesGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0002-1235-8291
Hassan S DashtiCenter for Genomic Medicine, Massachusetts General Hospital, Boston, 02114, MA, USA.ORCID http://orcid.org/0000-0002-1650-679X
Melvyn HillsdonSport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, EX1 2LU, UK.
Katherine S RuthGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-4966-9170
Marcus A TukeGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-0008-9263
Hanieh YaghootkarGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
Seth A SharpGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
Yingjie JieGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
William D ThompsonGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
Jamie W HarrisonGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0002-8314-9411
Amy DawesGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
Enda M ByrneThe University of Queensland, Institute for Molecular Bioscience, Brisbane, 4072, QLD, Australia.ORCID http://orcid.org/0000-0002-9491-7797
Henning TiemeierDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, GE, Netherlands.
Karla V AllebrandtDepartment of Translational Informatics, Translational Medicine Early Development, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Frankfurt, 65926, Germany.
Jack BowdenMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.
David W RayFaculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0002-4739-6773
Rachel M FreathyGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
Anna MurrayGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
Diego R MazzottiCenter for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, 19104, PA, USA.
Philip R GehrmanPerelman School of Medicine of the University of Pennsylvania, Philadelphia, 19104, PA, USA.
Debbie A LawlorMRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.ORCID http://orcid.org/0000-0002-6793-2262
Timothy M FraylingGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
Martin K RutterFaculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.
David A Hinds23andMe Inc., 899W. Evelyn Avenue, Mountain View, CA, 94041, USA.ORCID http://orcid.org/0000-0002-4911-803X
Richa SaxenaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, 02114, MA, USA.ORCID http://orcid.org/0000-0003-2233-1065
Michael N WeedonGenetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK. M.N.Weedon@exeter.ac.uk.
University of Exeter · GBBroad Institute · USUniversity of Bristol · GB23andMe (United States) · USBeth Israel Deaconess Medical Center · USCircadian (United States) · USErasmus MC · NLManchester Academic Health Science Centre · GBNetherlands eScience Center · NLSanofi (Germany) · DEThe University of Queensland · AUUniversity of Manchester · GBUniversity of Pennsylvania · US
Funding
TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5MGenetics of chronotype and impact on metabolic diseaseR01DK107859 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2016 to 2026
$4.0MMelatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK102696 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2015 to 2019
$3.8MImpact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2MGenetic and molecular basis of circadian rhythm disordersK01HL136884 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2018 to 2022
$848kImpact of genetic variants on sleep timing and type 2 diabetes riskF32DK102323 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2015 to 2016
$116kMedical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_UU_00011/2Medical Research Council MC_UU_00011/3Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_12013/5Medical Research Council MR/M005070/1Medical Research Council MR/P012167/1Medical Research Council MR/P023576/2NHLBI NIH HHS K01 HL136884NHLBI NIH HHS T32 HL007901NIDDK NIH HHS F32 DK102323NIDDK NIH HHS R01 DK102696NIDDK NIH HHS R01 DK105072NIDDK NIH HHS R01 DK107859Wellcome Trust 107851/Z/15/Z
Abstract
Being a morning person is a behavioural indicator of a person's underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing: the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 25 min earlier than the 5% carrying the fewest. The loci are enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. Using Mendelian Randomisation, we show that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes. This study offers insights into circadian biology and its links to disease in humans.
Indexed as
Circadian RhythmGenome-Wide Association StudyAdultAgedCyclic AMPFemaleGenetic LociGlutamic AcidHumansMaleMiddle AgedSleepUnited KingdomWhite PeopleCyclic AMPGlutamic Acid
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