Evidence map›Paper›PMID 30696807›Full record

Trial reportTranslational psychiatry2019

Placebo aiTBS attenuates suicidal ideation and frontopolar cortical perfusion in major depression.

Chris Baeken, Guo-Rong Wu, Kees van Heeringen

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01832805 (The Effects of Thetaburst Stimulation in Treatment Resistant Unipolar Depressed Patients), which is not on this map. Cited by 21 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01832805 nacompletednot on this map

The Effects of Thetaburst Stimulation in Treatment Resistant Unipolar Depressed Patients

TypeinterventionalSponsorUniversity GhentRan2013 to 2015Enrolled40ConditionsUnipolar Major DepressionArmsTheta burst stimulation.
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  7. Trial
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  9. Article
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  14. Suicidal Ideation and Obsessive-Compulsive Disorder: Links and Knowledge.Psychology research and behavior management · 2022
    Review
  15. Multimodal Elements of Suicidality Reduction After Transcranial Magnetic Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Chris BaekenDepartment of Head and Skin, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. chris.baeken@UGent.be.ORCID http://orcid.org/0000-0001-9885-3041
Guo-Rong WuKey Laboratory of Cognition and Personality, Faculty of Psychology, Southwest University, Chongqing, China.
Kees van HeeringenDepartment of Head and Skin, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0001-5801-194X
Ghent University · BEGhent University Hospital · BESouthwest University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of repetitive transcranial magnetic stimulation has been shown to rapidly decrease suicidal ideation in major depressive disorder (MDD). However, the neural working mechanisms behind this prompt attenuation of suicidal thoughts remains to be determined. Here, we examined how placebo-accelerated intermittent theta burst stimulation (aiTBS) may influence brain perfusion and suicidal thoughts using arterial spin labeling (ASL). In a randomized double-blind sham-controlled crossover trial, 45 MDD patients received aiTBS applied to the left dorsolateral prefrontal cortex (Trial registration: http://clinicaltrials.gov/show/NCT01832805 ). With each ASL scan measurement, suicidal ideation was assessed with the Beck Scale for Suicidal Ideation (BSI) and depression severity with the Beck Depression Inventory (BDI). Compared with active stimulation, the attenuation of suicidal ideation after 4 days of placebo aiTBS was related to significant frontopolar prefrontal perfusion decreases. These findings were unrelated to changes in depression severity scores. Although both active and sham aiTBS resulted in prompt decreases in suicidal ideation, specifically sham aiTBS significantly attenuated frontopolar perfusion in relation to reductions in BSI scores. Our findings show that in accelerated neurostimulation paradigms, placebo responses are related to perfusion decreases in brain areas associated with higher cognitive processes, resulting in suicidal ideation attenuation.

Indexed as

Suicidal IdeationAdultCross-Over StudiesDouble-Blind MethodFemaleHumansMajor Depressive DisorderMaleMiddle AgedPlacebo EffectPrefrontal CortexPsychiatric Status Rating ScalesTranscranial Magnetic Stimulation

Identifiers

PMID30696807
PMCPMC6351528
OpenAlexW2913762845

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.