ArticlemBio2019
Functional Metagenomics Reveals an Overlooked Diversity and Novel Features of Soil-Derived Bacterial Phosphatases and Phytases.
Article in mBio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Advances and Hotspots in Research on Verrucomicrobiota: Focus on Agroecosystems.Microbial ecology · 2025Review
- Thermotolerant class A acid phosphatase active across broad pH range and diverse substrates.Protein science : a publication of the Protein Society · 2025Article
- Inositol phosphates as an overlooked phosphorous source in marine ecosystems.The ISME journal · 2025Article
- Exploring the biotechnological potential of novel soil-derivedFrontiers in bioengineering and biotechnology · 2024Article
- Structural and functional profile of phytases across the domains of life.Current research in structural biology · 2024Review
- Construction of Small-Insert and Large-Insert Metagenomic Libraries.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Functional Metagenomics Approach for the Discovery of Novel Genes Encoding Phosphatase Activity.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Comparative Metagenomic Study of Rhizospheric and Bulk Mercury-Contaminated Soils in the Mining District of Almadén.Frontiers in microbiology · 2022Article
- Phytate and Microbial Suspension Amendments Increased Soybean Growth and Shifted Microbial Community Structure.Microorganisms · 2021Article
- Novel Soil-Derived Beta-Lactam, Chloramphenicol, Fosfomycin and Trimethoprim Resistance Genes Revealed by Functional Metagenomics.Antibiotics (Basel, Switzerland) · 2021Article
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- Article
- Characteristics of the First Protein Tyrosine Phosphatase with Phytase Activity from a Soil Metagenome.Genes · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphatases, including phytases, play a major role in cell metabolism, phosphorus cycle, biotechnology, and pathogenic processes. Nevertheless, their discovery by functional metagenomics is challenging. Here, soil metagenomic libraries were successfully screened for genes encoding phosphatase activity. In this context, we report the largest number and diversity of phosphatase genes derived from functional metagenome analysis. Two of the detected gene products carry domains which have never been associated with phosphatase activity before. One of these domains, the SNARE-associated domain DedA, harbors a so-far-overlooked motif present in numerous bacterial SNARE-associated proteins. Our analysis revealed a previously unreported phytase activity of the alkaline phosphatase and sulfatase superfamily (cl23718) and of purple acid phosphatases from nonvegetal origin. This suggests that the classical concept comprising four classes of phytases should be modified and indicates high performance of our screening method for retrieving novel types of phosphatases/phytases hidden in metagenomes of complex environments.
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