ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Deep Brain Stimulation Rescues Memory and Synaptic Activity in a Rat Model of Global Ischemia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Clinical study of the effects of deep brain stimulation on urinary dysfunctions in patients with Parkinson's disease.Clinical interventions in aging · 2019Trial
- Adenosine receptor signaling in vascular diseases: from molecular mechanisms to targeted therapeutics.Acta pharmacologica Sinica · 2026Review
- Neuromodulation and rehabilitation of post-stroke cognitive impairment: challenges and prospects.Frontiers in psychiatry · 2026Review
- Unraveling the potential of hypothalamic deep brain stimulation for obesity: Impacts on memory, neuroplasticity and brain metabolism in the Zucker rat.Translational psychiatry · 2025Article
- Resting-State Functional Magnetic Resonance Imaging Reveals the Effects of rTMS on Neural Activity and Brain Connectivity After Experimental Stroke.CNS neuroscience & therapeutics · 2024Article
- Engineering 3D Scaffold-Free Nanoparticle-Laden Stem Cell Constructs for Piezoelectric Enhancement of Human Neural Tissue Formation and Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease.Heliyon · 2024Review
- Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?IEEE open journal of engineering in medicine and biology · 2023Article
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
- Modulation of the rat hippocampal-cortex network and episodic-like memory performance following entorhinal cortex stimulation.CNS neuroscience & therapeutics · 2022Article
- Patterned Hippocampal Stimulation Facilitates Memory in Patients With a History of Head Impact and/or Brain Injury.Frontiers in human neuroscience · 2022Article
- Effects of hydroxyapatite extract on rats with transient ischemia: Long-term potentiation and axon regeneration.Experimental and therapeutic medicine · 2021Article
- Cordycepin Ameliorates Synaptic Dysfunction and Dendrite Morphology Damage of Hippocampal CA1Frontiers in cellular neuroscience · 2021Article
- Acupuncture accelerates neural regeneration and synaptophysin production after neural stem cells transplantation in mice.World journal of stem cells · 2020Article
- Intracranial alternating current stimulation facilitates neurogenesis in a mouse model of Alzheimer's disease.Alzheimer's research & therapy · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic stroke is responsible for a large number of neurological deficits including memory impairment. Deep brain stimulation (DBS), a well established therapeutic modality for the treatment of movement disorders, has recently shown potential beneficial effects on memory in animals and patients with Alzheimer's disease. Here, we test DBS for its ability to improve memory impairments by stimulating the entorhinal cortex (EC) in a rat model of global ischemia (GI). Two weeks after GI, adult male rats received high-frequency EC DBS for 1 h, and animals were assessed for changes in locomotor activity, learning, and memory 6 weeks later. GI produced spatial memory impairment that was ameliorated by DBS, with no difference between the group that received DBS for GI (GI-DBS ON group) and nonstroke control groups. Although GI led to a dramatic CA1 neuronal loss that could not be rescued with DBS, stimulation attenuated the reduction of CA1 synaptophysin expression after GI. Further,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.