Evidence map›Paper›PMID 30696730›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Enhanced Activation of HCN Channels Reduces Excitability and Spike-Timing Regularity in Maturing Vestibular Afferent Neurons.

Christopher M Ventura, Radha Kalluri

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Expression of hyperpolarization-activated current (Journal of neurophysiology · 2023
    Article
  8. Article
  9. Muscarinic Acetylcholine Receptors Modulate HCN Channel Properties in Vestibular Ganglion Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  10. Article
  11. Effects of Several Therapeutic Agents on Mammalian Vestibular Function: Meclizine, Diazepam, and JNJ7777120.Journal of the Association for Research in Otolaryngology : JARO · 2021
    Article
  12. Review
  13. Article
  14. Dopaminergic Inhibition of NaFrontiers in neuroscience · 2021
    Article
  15. Article
  16. Persistent and resurgent NaJournal of neurophysiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Christopher M VenturaNeuroscience Graduate Program.
Radha KalluriNeuroscience Graduate Program, radha@usc.edu.ORCID 0000-0002-0360-8965
Bioscience Research · USUniversity of Southern California · US

Funding

The role of ion channels in shaping the function of inner ear neuronsR01DC015512 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RADHA KALLURI · 2017 to 2026
$3.9M
Biophysical properties and function of primary auditory neuronsR03DC012652 · NIDCD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KALLURI, RADHA · 2013 to 2015
$701k
NIDCD NIH HHS R01 DC015512NIDCD NIH HHS R03 DC012652
6 · The paper itself

Abstract

Vestibular ganglion neurons (VGNs) transmit information along parallel neuronal pathways whose signature distinction is variability in spike-timing; some fire at regular intervals while others fire at irregular intervals. The mechanisms driving timing differences are not fully understood but two opposing (but not mutually exclusive) hypotheses have emerged. In the first, regular-spiking is inversely correlated to the density of low-voltage-gated potassium currents (

Indexed as

AgingAnimalsCyclic AMPElectrophysiological PhenomenaFemaleHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMaleMembrane PotentialsModels, NeurologicalNeurons, AfferentPatch-Clamp TechniquesPyrimidinesRatsRats, Long-EvansRecruitment, NeurophysiologicalVestibular NucleiCyclic AMPHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsICI D2788PyrimidinescAMPIHIKLneuronal excitabilityspike-timing regularityvestibular ganglion

Identifiers

PMID30696730
PMCPMC6462445
OpenAlexW2911599811

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.