ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Insensitivity of Place Cells to the Value of Spatial Goals in a Two-Choice Flexible Navigation Task.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Habit and the hippocampus: Model-based spatial representations without outcome-sensitive control.bioRxiv : the preprint server for biology · 2026Article
- A flexible hippocampal population code for experience relative to reward.Nature neuroscience · 2025Article
- Cortical dissociation of spatial reference frames during place navigation.bioRxiv : the preprint server for biology · 2025Article
- Article
- Unweaving the Cognitive Map: A Personal History.Hippocampus · 2025Review
- Neuronal activity in the ventral tegmental area during goal-directed navigation recorded by low-curvature microelectrode arrays.Microsystems & nanoengineering · 2024Article
- Selective reactivation of value- and place-dependent information during sharp-wave ripples in the intermediate and dorsal hippocampus.Science advances · 2024Article
- Article
- Distal but not local auditory information supports spatial representations by place cells.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Spontaneous Dynamics of Hippocampal Place Fields in a Model of Combinatorial Competition among Stable Inputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- A configural context signal simultaneously but separably drives positioning and orientation of hippocampal place fields.Hippocampus · 2024Article
- A manifold neural population code for space in hippocampal coactivity dynamics independent of place fields.Cell reports · 2023Article
- Do Place Cells Dream of Deceptive Moves in a Signaling Game?Neuroscience · 2023Review
- Article
- Neural dynamics underlying associative learning in the dorsal and ventral hippocampus.Nature neuroscience · 2023Article
- Learning to predict future locations with internally generated theta sequences.PLoS computational biology · 2023Article
- Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits.Cell reports · 2023Article
- Hippocampal representations of foraging trajectories depend upon spatial context.Nature neuroscience · 2022Article
- Neural circuit dynamics of drug-context associative learning in the mouse hippocampus.Nature communications · 2022Article
- Reward expectation extinction restructures and degrades CA1 spatial maps through loss of a dopaminergic reward proximity signal.Nature communications · 2022Article
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7 authors.
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Abstract
Hippocampal place cells show position-specific activity thought to reflect a self-localization signal. Several reports also point to some form of goal encoding by place cells. We investigated this by asking whether they also encode the value of spatial goals, which is crucial information for optimizing goal-directed navigation. We used a continuous place navigation task in which male rats navigate to one of two (freely chosen) unmarked locations and wait, triggering the release of reward, which is then located and consumed elsewhere. This allows sampling of place fields and dissociates spatial goal from reward consumption. The two goals varied in the amount of reward provided, allowing assessment of whether the rats factored goal value into their navigational choice and of possible neural correlates of this value. Rats successfully learned the task, indicating goal localization, and they preferred higher-value goals, indicating processing of goal value. Replicating previous findings, there was goal-related activity in the out-of-field firing of CA1 place cells, with a ramping-up of firing rate during the waiting period, but no general overrepresentation of goals by place fields, an observation that we extended to CA3 place cells. Importantly, place cells were not modulated by goal value. This suggests that dorsal hippocampal place cells encode space independently of its associated value despite the effect of that value on spatial behavior. Our findings are consistent with a model of place cells in which they provide a spontaneously constructed value-free spatial representation rather than encoding other navigationally relevant but nonspatial information.
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