Evidence map›Paper›PMID 30696720›Full record

ArticleMolecular pharmacology2019

Monod-Wyman-Changeux Allosteric Shift Analysis in Mutant

Andrea Szabo, Anahita Nourmahnad, Elizabeth Halpin, Stuart A Forman

Abstract read
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Activation of the human β3 GABABiochemical pharmacology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Modulation of the mammalian GABABritish journal of pharmacology · 2022
    Article
  9. Review
  10. Article
  11. The seizure-inducing plastic explosive RDX inhibits the α1β2γ2 GABAAnnals of clinical and translational neurology · 2022
    Article
  12. (+)-Catharanthine potentiates the GABABiochemical pharmacology · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Concatemers to re-investigate the role of α5 in α4β2 nicotinic receptors.Cellular and molecular life sciences : CMLS · 2021
    Article
  17. Article
  18. Binding site location on GABABritish journal of pharmacology · 2019
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrea SzaboBeecher-Mallinckrodt Laboratories, Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Anahita NourmahnadBeecher-Mallinckrodt Laboratories, Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Elizabeth HalpinBeecher-Mallinckrodt Laboratories, Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Stuart A FormanBeecher-Mallinckrodt Laboratories, Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts saforman@mgh.harvard.edu.

Funding

General Anesthetic Sites in GABA-A Receptor Subunit Interfacial PocketsR01GM089745 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI FORMAN, STUART A · 2010 to 2020
$3.8M
NIGMS NIH HHS R01 GM089745
6 · The paper itself

Abstract

Propofol, etomidate, and barbiturate anesthetics are allosteric coagonists at pentameric

Indexed as

AnestheticsAnimalsBarbituratesBinding SitesEtomidateFemaleMutationPropofolProtein SubunitsReceptors, GABA-AXenopus laevisAnestheticsBarbituratesbarbituric acidEtomidatePropofolProtein SubunitsReceptors, GABA-A

Identifiers

PMID30696720
PMCPMC6399575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.