Evidence map›Paper›PMID 30696718›Full record

ArticleMolecular pharmacology2019

Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9.

Tanya A Baldwin, Yong Li, Cameron S Brand, Val J Watts, Carmen W Dessauer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 47 citations in OpenAlex.

  1. Cells · 2026
    Article
  2. Review
  3. Prostacyclin enlists AC6 to stop the clot.Journal of thrombosis and haemostasis : JTH · 2025
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Inhibition of adenylyl cyclase by GTPase-deficient GαCell communication and signaling : CCS · 2024
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Cross-Talk Between the Adenylyl Cyclase/cAMP Pathway and CaReviews of physiology, biochemistry and pharmacology · 2021
    Review
  18. Article
  19. Nanometric targeting of type 9 adenylyl cyclase in heart.Biochemical Society transactions · 2019
    Review
  20. Regulation of ICells · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tanya A BaldwinDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas (T.A.B., Y.L., C.S.B., C.W.D.); and Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana (V.J.W.).ORCID 0000-0001-7142-639X
Yong LiDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas (T.A.B., Y.L., C.S.B., C.W.D.); and Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana (V.J.W.).
Cameron S BrandDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas (T.A.B., Y.L., C.S.B., C.W.D.); and Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana (V.J.W.).
Val J WattsDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas (T.A.B., Y.L., C.S.B., C.W.D.); and Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana (V.J.W.).
Carmen W DessauerDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, Texas (T.A.B., Y.L., C.S.B., C.W.D.); and Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana (V.J.W.) carmen.w.dessauer@uth.tmc.edu.
Purdue University West Lafayette · US

Funding

REGULATION OF ADENYLYL CYCLASE SIGNALING PATHWAYSR01GM060419 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DESSAUER, CARMEN W. · 2000 to 2021
$6.9M
Training in Pharmacological SciencesT32GM089657 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HANCOCK, JOHN F · 2010 to 2014
$728k
NIGMS NIH HHS R01 GM060419NIGMS NIH HHS T32 GM089657
6 · The paper itself

Abstract

Membrane-bound adenylyl cyclase (AC) isoforms have distinct regulatory mechanisms that contribute to their signaling specificity and physiologic roles. Although insight into the physiologic relevance of AC9 has progressed, the understanding of AC9 regulation is muddled with conflicting studies. Currently, modes of AC9 regulation include stimulation by G

Indexed as

Adenylyl CyclasesAnimalsCalcineurinCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell LineChlorocebus aethiopsColforsinCOS CellsCyclic AMPHEK293 CellsHumansProtein IsoformsProtein Kinase C betaSignal Transductionadenylate cyclase 9Adenylyl CyclasesCalcineurinCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2ColforsinCyclic AMPProtein IsoformsProtein Kinase C beta

Identifiers

PMID30696718
PMCPMC6399577
OpenAlexW2913659053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.