Evidence map›Paper›PMID 30696710›Full record

ArticleDevelopment (Cambridge, England)2019

Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea.

Zhili Hou, Qi Wu, Xin Sun, Huaiyong Chen, Yu Li, Yongchun Zhang, Munemasa Mori, Ying Yang, Jianwen Que, Ming Jiang

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Formation and function of multiciliated cells.The Journal of cell biology · 2024
    Review
  7. Article
  8. Article
  9. The role of Evi/Wntless in exporting Wnt proteins.Development (Cambridge, England) · 2023
    Review
  10. Review
  11. Molecular crosstalk in tracheal development and its recurrence in adult tissue regeneration.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. The development and stem cells of the esophagus.Development (Cambridge, England) · 2021
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Zhili HouCenter for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA.
Qi WuTianjin Haihe Hospital, Tianjin 300350, P.R. China.
Xin SunTianjin Haihe Hospital, Tianjin 300350, P.R. China.
Huaiyong ChenTianjin Haihe Hospital, Tianjin 300350, P.R. China.
Yu LiCenter for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA.
Yongchun ZhangCenter for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA.
Munemasa MoriCenter for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA.
Ying YangCenter for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA.
Jianwen QueCenter for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA jq2240@cumc.columbia.edu mj2735@cumc.columbia.edu.ORCID 0000-0002-6540-6701
Ming JiangCenter for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA jq2240@cumc.columbia.edu mj2735@cumc.columbia.edu.ORCID 0000-0002-8847-0351
Columbia University Irving Medical Center · USTianjin haihe hospital · CN

Funding

Regulatory Mechanisms of Cell Competition in Lung RegenerationR01HL148223 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MORI, MUNEMASA · 2019 to 2022
$2.1M
Nkx2.1+ Lung-Derived Cells in Asthma and Eosinophilic Esophagitis (EoE)R01HL132996 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN · 2017 to 2020
$2.0M
NHLBI NIH HHS R01 HL132996NHLBI NIH HHS R01 HL148223
6 · The paper itself

Abstract

Basal progenitor cells are crucial for the establishment and maintenance of the tracheal epithelium. However, it remains unclear how these progenitor cells are specified during foregut development. Here, we found that ablation of the Wnt chaperone protein Gpr177 (also known as Wntless) in mouse tracheal epithelium causes a significant reduction in the number of basal progenitor cells accompanied by cartilage loss in

Indexed as

Animalsbeta CateninFibroblast Growth Factor 10Hedgehog ProteinsMiceMice, Mutant StrainsReceptor, Fibroblast Growth Factor, Type 2Repressor ProteinsRespiratory MucosaTracheaTwist-Related Protein 1Wnt Signaling Pathwaybeta CateninCTNNB1 protein, mouseFgf10 protein, mouseFgfr2 protein, mouseFibroblast Growth Factor 10Hedgehog ProteinsReceptor, Fibroblast Growth Factor, Type 2Repressor ProteinsShh protein, mouseTwist2 protein, mouseTwist-Related Protein 1AirwayBasal progenitorCartilageFgfMouseWntlessWnt/β-catenin

Identifiers

PMID30696710
PMCPMC6382003
OpenAlexW2914788249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.