Evidence map›Paper›PMID 30696523›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2019

Interim estimates of 2018/19 vaccine effectiveness against influenza A(H1N1)pdm09, Canada, January 2019.

Danuta M Skowronski, Siobhan Leir, Suzana Sabaiduc, Michelle Murti, James A Dickinson, Romy Olsha, Jonathan B Gubbay, Matthew A Croxen, Hugues Charest, Tracy Chan and 4 more

Abstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Influenza vaccine effectiveness from nine studies during drifted A(H3N2) subclade K predominance, Europe, September 2025 to January 2026.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Influenza Vaccine Effectiveness in Australia During 2017-2019.Influenza and other respiratory viruses · 2025
    Article
  6. Review
  7. Article
  8. Does the Australian influenza season predict the Canadian influenza season? A qualitative comparison of seasons, 2014-2020.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2023
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Interim estimates of 2019/20 vaccine effectiveness during early-season co-circulation of influenza A and B viruses, Canada, February 2020.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020
    Article
  17. Article
  18. Article
  19. Paradoxical clade- and age-specific vaccine effectiveness during the 2018/19 influenza A(H3N2) epidemic in Canada: potential imprint-regulated effect of vaccine (I-REV).Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019
    Article
  20. Intense interseasonal influenza outbreaks, Australia, 2018/19.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Danuta M SkowronskiBritish Columbia Centre for Disease Control, Vancouver, Canada.
Siobhan LeirBritish Columbia Centre for Disease Control, Vancouver, Canada.
Suzana SabaiducBritish Columbia Centre for Disease Control, Vancouver, Canada.
Michelle MurtiPublic Health Ontario, Toronto, Canada.
James A DickinsonUniversity of Calgary, Calgary, Canada.
Romy OlshaPublic Health Ontario, Toronto, Canada.
Jonathan B GubbayPublic Health Ontario, Toronto, Canada.
Matthew A CroxenProvincial Laboratory for Public Health, Edmonton, Canada.
Hugues CharestInstitut National de Santé Publique du Québec, Quebec City, Canada.
Tracy ChanBritish Columbia Centre for Disease Control, Vancouver, Canada.
Nathalie BastienNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Yan LiNational Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.
Mel KrajdenBritish Columbia Centre for Disease Control, Vancouver, Canada.
Gaston De SerresLaval University, Quebec City, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using a test-negative design, the Canadian Sentinel Practitioner Surveillance Network assessed interim 2018/19 vaccine effectiveness (VE) against predominant influenza A(H1N1)pdm09 viruses. Adjusted VE was 72% (95% confidence interval: 60 to 81) against medically attended, laboratory-confirmed influenza A(H1N1)pdm09 illness. This substantial vaccine protection was observed in all age groups, notably young children who appeared to be disproportionately affected. Sequence analysis identified heterogeneity in emerging clade 6B.1 viruses but no dominant drift variant.

Indexed as

Vaccine PotencyAdolescentAdultAgedCanadaCase-Control StudiesChildChild, PreschoolFemaleHemagglutination Inhibition TestsHumansInfantInfluenza A Virus, H1N1 SubtypeInfluenza, HumanInfluenza VaccinesMaleInfluenza VaccinesCanadaepidemiologygenomicsILIimmunisationinfluenzainfluenza-like illnessinfluenza viruslaboratoryvaccine effectivenessvaccine-preventable diseasesvaccinesviral infections

Identifiers

PMID30696523
PMCPMC6351998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.