Evidence map›Paper›PMID 30696454›Full record

Trial reportBMC women's health2019

Effects of aerobic and resistance exercises on circulating apelin-12 and apelin-36 concentrations in obese middle-aged women: a randomized controlled trial.

Sun-Hwa Jang, Il-Young Paik, Jae-Hoon Ryu, Tae-Hyung Lee, Dae-Eun Kim

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC women's health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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  6. Myokines and mitochondrial function in cardiometabolic diseases.Journal of physiology and biochemistry · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sun-Hwa JangExercise Physiology Laboratory, Department of Physical Education, Yonsei University, Seoul, 03722, South Korea.
Il-Young PaikExercise Physiology Laboratory, Department of Physical Education, Yonsei University, Seoul, 03722, South Korea.
Jae-Hoon RyuExercise Physiology Laboratory, Department of Physical Education, Yonsei University, Seoul, 03722, South Korea.
Tae-Hyung LeeExercise Physiology Laboratory, Department of Physical Education, Yonsei University, Seoul, 03722, South Korea.
Dae-Eun KimExercise Physiology Laboratory, Department of Physical Education, Yonsei University, Seoul, 03722, South Korea. kde0528@hanmail.net.ORCID 0000-0002-3319-0459
Yonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe risk for obesity-related diseases increases with the prevalence of obesity. In obesity, adipokines secreted from adipose tissue induce inflammation, causing adverse effects. Recently, adipokines such as apelin, visfatin, and chemerin have been studied. Long-term resistance training improves health in middle-aged women by improving metabolic risk factors, body composition, and muscle strength. However, there is still a lack of evidence on the association of apelin concentration with different exercise types in middle-aged obese women This study aimed to investigate the effects of 8 weeks of aerobic and resistance exercises on apelin-12 and apelin-36 levels and thereby verify the effects of different exercise types in obese, middle-aged women.

methodsParticipants were middle-aged women aged 50-61 years, with no experience of systematic exercise in the last 6 months, and met the WHO obesity criteria for the Asia-Pacific region of waist circumference ≥ 80 cm and body fat percentage ≥ 30%. Subjects were selected and allocated to the aerobic exercise, resistance exercise, or no exercise group by block randomization. Body weight, body fat, and body mass index were measured by bioelectrical impedance analysis. Analysis of variance, the t-test, and Tukey's post-hoc test were performed.

resultsA total of 24 participants were selected with eight participants in each group. Both aerobic and resistance exercises were effective in altering the physical composition, showing significant decreases in weight, waist circumference, BMI, and body fat. The aerobic and resistance exercise group showed a significant, positive change in apelin-12 levels.

conclusionsIn obese individuals, aerobic and resistance exercise were effective in improving obesity and reducing blood apelin-12 concentration, which is closely correlated with indicators of metabolic syndrome. Future research should focus on comparing the response of apelin to exercise in obese subjects treated with only dietary control and the response in the obese subjects of different ages and sex.

trial registrationNo. 1040917-201,506-BR-153-04 , Clinical Research Information Service (CRIS), Republic of Korea (05 October 2018, retrospectively registered).

Indexed as

Resistance TrainingApelinBody CompositionBody Mass IndexBody WeightExerciseExercise TherapyFemaleHumansIntercellular Signaling Peptides and ProteinsMaleMetabolic SyndromeMiddle AgedObesityRepublic of KoreaRetrospective StudiesApelinapelin-12 peptideAPLN protein, humanIntercellular Signaling Peptides and ProteinsAerobic exerciseApelin-12Apelin-36Obese middle-aged womenResistance exercise

Identifiers

PMID30696454
PMCPMC6352322
OpenAlexW2920608352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.