Evidence map›Paper›PMID 30696423›Full record

Trial reportBMC gastroenterology2019

High-intensity interval training and moderate-intensity continuous training in adults with Crohn's disease: a pilot randomised controlled trial.

Garry A Tew, Dean Leighton, Roger Carpenter, Simon Anderson, Louise Langmead, John Ramage, James Faulkner, Elizabeth Coleman, Caroline Fairhurst, Michael Seed and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 8 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 8 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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  5. Rates of compliance and adherence to high-intensity interval training: a systematic review and Meta-analyses.The international journal of behavioral nutrition and physical activity · 2023
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  8. Interventions for fatigue in inflammatory bowel disease.The Cochrane database of systematic reviews · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 1 country.

Garry A TewDepartment of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle-upon-Tyne, NE1 8ST, UK. garry.tew@northumbria.ac.uk.ORCID http://orcid.org/0000-0002-8610-0613
Dean LeightonCentre for Immunobiology, Queen Mary University of London, Blizard Building, Newark Street, Whitechapel, London, E1 2AT, UK.
Roger CarpenterSchool of Health, Sport and Bioscience, University of East London, Stratford Campus, London, E15 4LZ, UK.
Simon AndersonGuy's and St Thomas' NHS Foundation Trust, London, UK.
Louise LangmeadDigestive Diseases Clinical Academic Unit, Barts and the London NHS Trust, London, UK.
John RamageHampshire Hospitals NHS Foundation Trust, Hampshire, UK.
James FaulknerDepartment of Sport, Exercise and Health, University of Winchester, Winchester, SO22 4NR, UK.
Elizabeth ColemanYork Trials Unit, University of York, Heslington, York, YO10 5DD, UK.
Caroline FairhurstYork Trials Unit, University of York, Heslington, York, YO10 5DD, UK.
Michael SeedSchool of Health, Sport and Bioscience, University of East London, Stratford Campus, London, E15 4LZ, UK.
Lindsay BottomsCentre for Psychology and Sports Science, University of Hertfordshire, Life and Medical Sciences, CP Snow Building, College Lane, Hatfield, AL10 9AB, UK.
University of East London · GBUniversity of York · GBBarts Health NHS Trust · GBGuy's and St Thomas' NHS Foundation Trust · GBHampshire Hospitals NHS Foundation Trust · GBNorthumbria University · GBQueen Mary University of London · GBUniversity of Hertfordshire · GBUniversity of Winchester · GB

Funding

Crohn's and Colitis UK SP2015/1
6 · The paper itself

Abstract

backgroundThis study assessed the feasibility and acceptability of two common types of exercise training-high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)-in adults with Crohn's disease (CD).

methodsIn this mixed-methods pilot trial, participants with quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT or usual care control, and followed up for 6 months. The HIIT and MICT groups were offered three exercise sessions per week for the first 12 weeks. Feasibility outcomes included rates of recruitment, retention, outcome completion, and exercise attendance. Data were collected on cardiorespiratory fitness (e.g., peak oxygen uptake), disease activity, fatigue, quality of life, adverse events, and intervention acceptability (via interviews).

resultsOver 17 months, 53 patients were assessed for eligibility and 36 (68%) were randomised (47% male; mean age 36.9 [SD 11.2] years); 13 to HIIT, 12 to MICT, and 11 to control. The exercise session attendance rate was 62% for HIIT (288/465) and 75% for MICT (320/429), with 62% of HIIT participants (8/13) and 67% of MICT participants (8/12) completing at least 24 of 36 sessions. One participant was lost to follow-up. Outcome completion rates ranged from 89 to 97%. The mean increase in peak oxygen uptake, relative to control, was greater following HIIT than MICT (2.4 vs. 0.7 mL/kg/min). There were three non-serious exercise-related adverse events, and two exercise participants experienced disease relapse during follow-up.

conclusionsThe findings support the feasibility and acceptability of the exercise programmes and trial procedures. A definitive trial is warranted. Physical exercise remains a potentially useful adjunct therapy in CD. [ID: ISRCTN13021107].

Indexed as

AdultAnxietyCardiorespiratory FitnessCrohn DiseaseDepressionEndurance TrainingFatigueFeasibility StudiesFemaleHigh-Intensity Interval TrainingHumansMaleMiddle AgedPatient Acceptance of Health CarePatient CompliancePilot ProjectsExercise therapyInflammatory bowel diseaseRandomised controlled trial

Identifiers

PMID30696423
PMCPMC6352351
OpenAlexW2916111674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.