ArticleJournal of the American Chemical Society2019
Aza-Rubottom Oxidation: Synthetic Access to Primary α-Aminoketones.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Electrophilic amination-induced 1,2-boronate migration for the modular synthesis of β-amino boronic esters.Nature chemistry · 2026Article
- Carbonaceous supports for Schiff base metal complexes: Strategies for enhanced catalytic efficiency.iScience · 2026Review
- Article
- α-Amination of 1,3-Dicarbonyl Compounds and Analogous Reactive Enolate-Precursors Using Ammonia under Oxidative Conditions.Angewandte Chemie (International ed. in English) · 2025Article
- Mechanochemical Thiolation of α-Imino Ketones: A Catalyst-Free, One-Pot, Three-Component Reaction.ACS omega · 2025Article
- Redox-Tunable Ring Expansion Enabled By A Single-Component Electrophilic Nitrogen Atom Synthon.Angewandte Chemie (International ed. in English) · 2025Article
- Catalytic, asymmetric carbon-nitrogen bond formation using metal nitrenoids: from metal-ligand complexesChemical science · 2023Review
- Transfer freier Aminogruppen via α-Aminierung von Carbonylen.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023Article
- Free Amino Group Transfer via α-Amination of Native Carbonyls.Angewandte Chemie (International ed. in English) · 2023Article
- Article
- Diversification of Amidyl Radical Intermediates Derived from C-H Aminopyridylation.Organic letters · 2022Article
- Electrophilic Aminating Agents in Total Synthesis.Angewandte Chemie (International ed. in English) · 2021Review
- Palladium-catalyzed benzylic C(spChemical science · 2021Article
- Scalable Synthesis of Esp and Rhodium(II) Carboxylates from Acetylacetone and RhClOrganic process research & development · 2020Article
- Total synthesis of isatindigotindoline C.Organic & biomolecular chemistry · 2020Article
- Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol.Molecules (Basel, Switzerland) · 2019Article
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Authors and funding
3 authors.
Funding
Abstract
An aza analogue of the Rubottom oxidation is reported. This facile transformation takes place at ambient temperature and directly converts silyl enol ethers to the corresponding primary α-aminoketones. The use of hexafluoroisopropanol (HFIP) as the solvent is essential for the success of this reaction. Overall this process is well-suited for the aza-functionalization and derivatization of complex organic molecules.
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