Evidence map›Paper›PMID 30696031›Full record

ReviewMarine drugs2019

Quorum Sensing Inhibitors from Marine Microorganisms and Their Synthetic Derivatives.

Jianwei Chen, Bixia Wang, Yaojia Lu, Yuqi Guo, Jiadong Sun, Bin Wei, Huawei Zhang, Hong Wang

Open access · goldAbstract readReview
In one paragraph

Review in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Love at First Taste: Induction of Larval Settlement by Marine Microbes.International journal of molecular sciences · 2020
    Pooled it
  3. Article
  4. Article
  5. Article
  6. Research Progress on the Quorum Sensing System ofPathogens (Basel, Switzerland) · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Quorum Sensing Inhibition by Sponge-AssociatedAntibiotics (Basel, Switzerland) · 2025
    Article
  11. Anti-QS Strategies AgainstMicroorganisms · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Molecular Aspects of the Functioning of Pathogenic Bacteria Biofilm Based onInternational journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jianwei ChenCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. cjw983617@zjut.edu.cn.
Bixia WangCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. 15757116051@163.com.
Yaojia LuCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. lyj512637@zjut.edu.cn.
Yuqi GuoCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. m17816038135_1@163.com.
Jiadong SunLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20878, USA. jiadong.sun@nih.gov.
Bin WeiCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. binwei@zjut.edu.cn.
Huawei ZhangCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. hwzhang@zjut.edu.cn.ORCID 0000-0002-2430-3845
Hong WangCollege of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China. hongw@zjut.edu.cn.ORCID 0000-0003-0058-060X
Zhejiang University of Technology · CNNational Institutes of Health · US

Funding

National Key R&D Program of China 2018YFC0311003National Key Research and Development Program of China 2017YFE0103100National Natural Science Foundation of China 41776139National Natural Science Foundation of China 81741165National Natural Science Foundation of China 81773628
6 · The paper itself

Abstract

Quorum sensing inhibitors (QSIs) present a promising alternative or potent adjuvants of conventional antibiotics for the treatment of antibiotic-resistant bacterial strains, since they could disrupt bacterial pathogenicity without imposing selective pressure involved in antibacterial treatments. This review covers a series of molecules showing quorum sensing (QS) inhibitory activity that are isolated from marine microorganisms, including bacteria, actinomycetes and fungi, and chemically synthesized based on QSIs derived from marine microorganisms. This is the first comprehensive overview of QSIs derived from marine microorganisms and their synthetic analogues with QS inhibitory activity.

Indexed as

Aquatic OrganismsDrug Resistance, BacterialAnti-Bacterial AgentsBacteriaFungiQuorum SensingAnti-Bacterial Agentsderivativesmarine microorganismquorum sensingquorum sensing inhibitor

Identifiers

PMID30696031
PMCPMC6409935
OpenAlexW2913198824

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.