ArticleAnimals : an open access journal from MDPI2019
PDGFA in Cashmere Goat: A Motivation for the Hair Follicle Stem Cells to Activate.
Article in Animals : an open access journal from MDPI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Exploring the Cyclic Patterns of Secondary Hair Follicles in Cashmere Goats Based on Skin Transcriptome Data.Animals : an open access journal from MDPI · 2026Article
- Investigating RNA-Seq-based differential gene expression during hair follicle development in Angora goat skin.Journal of animal science and technology · 2026Article
- Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats.Scientific reports · 2025Article
- Knockdown of miR-361-5p promotes the induced activation of SHF-stem cells through FOXM1 mediated Wnt/β-catenin pathway in cashmere goats.Animal biotechnology · 2024Article
- Phenotypic Correlation between Guard Hair and Down Hair in Chinese Alashan Left Banner White Cashmere Goat: A Preliminary Study.Animals : an open access journal from MDPI · 2023Article
- N6-Methyladenosine modification (m6A) of circRNA-ZNF638 contributes to the induced activation of SHF stem cells through miR-361-5p/Wnt5a axis in cashmere goats.Animal bioscience · 2023Article
- Hair Follicle Development and Cashmere Traits in Albas Goat Kids.Animals : an open access journal from MDPI · 2023Article
- Effects of exogenous melatonin on expressional differences of immune-related genes in cashmere goats.Frontiers in genetics · 2022Article
- Identification of Genes Related to Hair Follicle Cycle Development in Inner Mongolia Cashmere Goat by WGCNA.Frontiers in veterinary science · 2022Article
- Shedding light on cashmere goat hair follicle biology: from morphology analyses to transcriptomic landascape.BMC genomics · 2020Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
The cashmere hair follicle (HF) perpetually goes through cycles of growth, involution and rest. The photoperiod is the main factor in the control of seasonal coat change in cashmere goats while stem cells play a crucial role in the HF growth. Several factors, including Platelet-Derived Growth Factor A (PDGFA), Bone Morphogenetic Protein 2 (BMP2) and Lim-Homeobox gene 2 (LHX2) are implicated in HF morphogenesis and cycle. In this work, the mentioned molecules were investigated to evaluate their role in follicular cycle activation. The study was performed on skin samples collected at different periods of HF cycle and the molecular expression of PDGFA, BMP2 and LHX2 was evaluated by Real-Time PCR (qPCR) at each time point. Since PDGFA showed the most variation, the goat PDGFA gene was sequenced and the protein localization was investigated by immunohistochemistry together with PDGF receptor α (PDGFRα). PDGFA immunostaining was observed in the basal layer of the HF outer root sheath and the immunoreaction appeared stronger in the regressive HFs compared to those in the anagen phase according to qPCR analysis. PDGFRα was observed in the HF epithelium, proving the effect of PDGFA on the follicular structure. The data obtained suggest that PDGFA and BMP2 are both implicated in HF cycle in goat. In particular, PDGFA secreted by the HF is involved in the anagen activation.
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Registered trials
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