Evidence map›Paper›PMID 30695738›Full record

ReviewBone2019

Effects of disease-afflicted and aging neurons on the musculoskeletal system.

Gregorio Valdez

Open access · greenAbstract readReview
In one paragraph

Review in Bone, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Quantity and Distribution of Muscle Spindles in Animal and Human Muscles.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Gregorio ValdezFralin Biomedical Research Institute, Virginia Tech Carilion, Roanoke, VA, USA; Department of Biological Sciences, Virginia Tech, Blacksburg, VA, USA. Electronic address: gvaldez1@vtc.vt.edu.
Virginia Cooperative Extension · US

Funding

Targeting the fibroblast growth factor binding protein-1 to slow degeneration of neuromuscular junctionsR01AG055545 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2017 to 2021
$2.2M
Analysis of Sensory Neurons to Understand and Identify Factors to Treat ALSR21NS106313 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2018 to 2019
$433k
Dysregulated cholinergic transmission contributes to aging of the lower motor systemR56AG054898 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2017 to 2017
$394k
NIA NIH HHS R01 AG055545NIA NIH HHS R56 AG054898NINDS NIH HHS R21 NS106313
6 · The paper itself

Abstract

The musculoskeletal system includes skeletal muscles, bones and innervating axons from neurons in the central and peripheral nervous systems. Together, they form the largest structure in the body. They also initiate and coordinate locomotion, provide structural stability, and contribute to metabolism and homeostasis. Because of these functions, much effort has been devoted to ascertaining the impact of acute and chronic stress, such as disease, injury and aging, on the musculoskeletal system. This review will examine the role of the nervous system in the deleterious changes that accrue in skeletal muscles and bones during the progression of neurologic diseases and with advancing age.

Indexed as

AgingAnimalsHumansMotor NeuronsMuscle, SkeletalMusculoskeletal SystemNeuromuscular DiseasesNeuromuscular JunctionAgingDiseasesMotor NeuronsNeuromuscular junctionSensory NeuronsSympathetic NeuronsSynapse

Identifiers

PMID30695738
PMCPMC6444351
OpenAlexW2914516331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.