Evidence map›Paper›PMID 30695720›Full record

ArticleMagnetic resonance imaging2019

Tissue sodium concentration and sodium T

Arthur Coste, Fawzi Boumezbeur, Alexandre Vignaud, Guillaume Madelin, Kathrin Reetz, Denis Le Bihan, Cécile Rabrait-Lerman, Sandro Romanzetti

Abstract read
In one paragraph

Article in Magnetic resonance imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Magnetic resonance in medicine · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Hardware and Software Setup for QuantitativeSensors (Basel, Switzerland) · 2024
    Article
  7. Review
  8. Clinically feasible BNMR in biomedicine · 2023
    Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Evaluation of Sodium (In vivo (Athens, Greece)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Arthur CosteNeuroSpin, CEA DRF-ISVFJ, Paris-Saclay University, Gif-sur-Yvette, France.
Fawzi BoumezbeurNeuroSpin, CEA DRF-ISVFJ, Paris-Saclay University, Gif-sur-Yvette, France.
Alexandre VignaudNeuroSpin, CEA DRF-ISVFJ, Paris-Saclay University, Gif-sur-Yvette, France.
Guillaume MadelinCenter for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, USA.
Kathrin ReetzDepartment of Neurology, RWTH Aachen University, Aachen, Germany; JARA-BRAIN Institute of Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH Aachen University, Aachen, Germany.
Denis Le BihanNeuroSpin, CEA DRF-ISVFJ, Paris-Saclay University, Gif-sur-Yvette, France.
Cécile Rabrait-LermanNeuroSpin, CEA DRF-ISVFJ, Paris-Saclay University, Gif-sur-Yvette, France.
Sandro RomanzettiDepartment of Neurology, RWTH Aachen University, Aachen, Germany. Electronic address: sromanzetti@ukaachen.de.
Commissariat à l'Énergie Atomique et aux Énergies Alternatives · FRForschungszentrum Jülich · DENew York University · USRWTH Aachen University · DE

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
Simultaneous Multinuclear Magnetic Resonance Fingerprinting for Data Fusion of Quantitative Structural and Metabolic ImagingR01EB026456 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MADELIN, GUILLAUME · 2018 to 2021
$2.6M
Quantitative Sodium MR Imaging and Proton MR Spectroscopy in Traumatic Brain InjuryR01NS097494 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KIROV, IVAN IVANOV, MADELIN, GUILLAUME · 2016 to 2020
$2.4M
Metabolic Sodium MRI to Assess Early Response of Breast Cancer to Neoadjuvant ChemotherapyR21CA213169 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BROWN, RYAN, MADELIN, GUILLAUME · 2017 to 2018
$406k
Sodium MRI of the HipR03AR065763 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MADELIN, GUILLAUME · 2014 to 2015
$170k
NCI NIH HHS R21 CA213169NIAMS NIH HHS R03 AR065763NIBIB NIH HHS P41 EB017183NIBIB NIH HHS R01 EB026456NINDS NIH HHS R01 NS097494
6 · The paper itself

Abstract

purposeThe state-of-the-art method to quantify sodium concentrations in vivo consists in a fully relaxed 3D spin-density (SD) weighted acquisition. Nevertheless, most sodium MRI clinical studies use short-TR SD acquisitions to reduce acquisition durations. We present a clinically viable implementation of the Variable Flip Angle (VFA) method for robust and clinically viable quantification of total sodium concentration (TSC) and longitudinal relaxation rates in vivo in human brain at 3 T.

methodsTwo non-Cartesian steady-state spoiled ultrashort echo time (UTE) scans, performed at optimized flip angles, repetition time and pulse length determined under specific absorption rate constraints, are used to simultaneously compute T

resultsThe VFA method resulted in consistent TSC and T

conclusionThe VFA method can be applied successfully to image sodium at 3 T in about 20 min and provides robust and intrinsically T

Indexed as

AdultAlgorithmsBrainBrain MappingComputer SimulationFemaleFourier AnalysisHealthy VolunteersHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMagneticsMaleMiddle AgedModels, StatisticalPhantoms, ImagingSodium(23)Na MRIT(1) mappingTissue sodium concentrationVariable Flip Angle

Identifiers

PMID30695720
PMCPMC6927040
OpenAlexW2912062515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.