ArticlePloS one2019
Chemical composition, antioxidant, anti-inflammatory, and cytotoxic activities of Opuntia stricta cladodes.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 70 citations in OpenAlex.
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- Antioxidant Potential, Genotoxic Safety, and Metabolomic Profiling of Cladode Extracts fromAntioxidants (Basel, Switzerland) · 2026Article
- In Vitro Antidiabetic Activity and Mechanism of Action of Methanolic Extract of Opuntia stricta Cladodes.BioMed research international · 2026Article
- Comparative antioxidant activity of four Omani medicinal plants:Open veterinary journal · 2025Article
- Identification, Quantification, and Antioxidant Evaluation of Phenolic Compounds from ColoredAntioxidants (Basel, Switzerland) · 2025Article
- Opuntia ficus-indica cladodes extract inhibits human neutrophil pro-inflammatory functions and protects rats from acetic acid-induced ulcerative colitis.Inflammopharmacology · 2024Article
- Phytochemicals, antioxidant, and antimicrobial activities ofOpen veterinary journal · 2024Article
- GC-MS analysis, phytochemical composition ofRSC advances · 2024Article
- Chemical Composition, Nutritional Value, Antioxidative, andACS omega · 2024Article
- Cladodes ofPlants (Basel, Switzerland) · 2024Article
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- Nutritional Quality of Milk Fat from Cows Fed Full-Fat Corn Germ in Diets Containing Cactus Opuntia and Sugarcane Bagasse as Forage Sources.Animals : an open access journal from MDPI · 2023Article
- Phytochemical Screening and Bioactivities of Cactaceae Family Members Endemic to Mexico.Plants (Basel, Switzerland) · 2022Article
- In Vitro Cytotoxic Activity of African Plants: A Review.Molecules (Basel, Switzerland) · 2022Review
- Phenolic Compounds' Occurrence inMolecules (Basel, Switzerland) · 2022Review
- Alternative and Unconventional Feeds in Dairy Diets and Their Effect on Fatty Acid Profile and Health Properties of Milk Fat.Animals : an open access journal from MDPI · 2021Review
- Protective Effect ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Antioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves ofMolecules (Basel, Switzerland) · 2020Article
- Antioxidant and Anti-Obesity Activities ofJournal of microbiology and biotechnology · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Opuntia spp. have been used in traditional medicine for many centuries. It is used in the management of diseases that involves oxidative stress, especially diabetes, obesity and cancer. Opuntia stricta (Haw) is one of the relatively unknown species in South Africa where it is regarded more as a weed. Because of this, not much is known about its chemical composition.
aimTo determine the chemical composition, antioxidant, anti-inflammatory, and cytotoxic activities of Opuntia stricta cladodes.
methodsThe phytochemical composition of acetone, aqueous and ethanol extract of cladodes of Opuntia stricta (Haw), as well as the vitamins A, C and E of its dried weight cladodes and the antioxidant activities, were evaluated using standard in vitro methods. The anti-inflammatory and cytotoxic activities were evaluated using cell-based assays. The phytochemical composition and vitamins were determined spectrophotometrically, while the antioxidant activities were determined by DPPH, nitric oxide, hydrogen peroxide scavenging activity and phosphomolybdenum (total) antioxidant activity. Anti-inflammatory activity was determined using RAW 264.7 cells, while cytotoxicity was determined using U937 cells.
resultsThe phytochemical composition showed a significant difference in the various extracts. The total phenolics were higher than other phytochemicals in all the extracts used. All the extracts displayed antioxidant activity, while most of the extracts showed anti-inflammatory activity. Only one extract showed cytotoxicity, and it was mild.
conclusionThe results show that the Opuntia stricta is rich in polyphenolic compounds and has good antioxidant activity as well as anti-inflammatory activities.
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