ArticlePLoS biology2019
Dominance reversals and the maintenance of genetic variation for fitness.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed.
- Characterizing the detectable and invisible fractions of genomic loci under balancing selection.Molecular biology and evolution · 2026Article
- Sexual antagonism, mating systems, and recombination suppression on sex chromosomes.Evolution letters · 2026Article
- The geometry of dominance shows broad potential for stable polymorphism under antagonistic pleiotropy.bioRxiv : the preprint server for biology · 2026Article
- A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Article
- Selection Estimation from Genetic Time-Series Data: Effects of Limited Sampling and Genetic Drift.Molecular biology and evolution · 2025Article
- Beneficial reversal of dominance maintains a large-effect resistance polymorphism under fluctuating insecticide selection.Nature ecology & evolution · 2025Article
- Effects of inbreeding on balancing selection: insights from Fisher's geometric model.Genetics · 2025Article
- A Balanced Inversion Polymorphism Exhibits a Dominance Reversal at the Gene Expression Level that Depends on Developmental Context.Molecular biology and evolution · 2025Article
- Pervasive fitness trade-offs revealed by rapid adaptation to shifting population densities in large experimental populations ofbioRxiv : the preprint server for biology · 2025Article
- Linking individual fitness to the evolution of cognition.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Season-specific dominance broadly stabilizes polymorphism under symmetric and asymmetric multivoltinism.Genetics · 2025Article
- The potential of inversions to accumulate balanced sexual antagonism is supported by simulations andeLife · 2025Article
- The maintenance of genetic polymorphism underlying sexually antagonistic traits.Evolution letters · 2025Article
- How does plant chemodiversity evolve? Testing five hypotheses in one population genetic model.The New phytologist · 2025Article
- Sex-Specific Dominance of Gene Expression in Seed Beetles.Molecular biology and evolution · 2024Article
- Cis-regulatory Variation in Relation to Sex and Sexual Dimorphism in Drosophila melanogaster.Genome biology and evolution · 2024Article
- Structural genomic variation and behavioral interactions underpin a balanced sexual mimicry polymorphism.Current biology : CB · 2024Article
- On the resolution of sexual conflict over shared traits.Proceedings. Biological sciences · 2024Review
- Dominance reversals: the resolution of genetic conflict and maintenance of genetic variation.Proceedings. Biological sciences · 2024Review
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Abstract
Antagonistic selection between different fitness components (e.g., survival versus fertility) or different types of individuals in a population (e.g., females versus males) can potentially maintain genetic diversity and thereby account for the high levels of fitness variation observed in natural populations. However, the degree to which antagonistic selection can maintain genetic variation critically depends on the dominance relations between antagonistically selected alleles in diploid individuals. Conditions for stable polymorphism of antagonistically selected alleles are narrow, particularly when selection is weak, unless the alleles exhibit "dominance reversals"-in which each allele is partially or completely dominant in selective contexts in which it is favored and recessive in contexts in which it is harmful. Although theory predicts that dominance reversals should emerge under biologically plausible conditions, evidence for dominance reversals is sparse. In this primer, we review theoretical arguments and data supporting a role for dominance reversals in the maintenance of genetic variation. We then highlight an illuminating new study by Grieshop and Arnqvist, which reports a genome-wide signal of dominance reversals between male and female fitness in seed beetles.
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