Evidence map›Paper›PMID 30694974›Full record

Trial reportMedicine and science in sports and exercise2019

Histamine-Receptor Antagonists Slow 10-km Cycling Performance in Competitive Cyclists.

Matthew R Ely, Dylan C Sieck, Joshua E Mangum, Emily A Larson, Leandro C Brito, Christopher T Minson, John R Halliwill

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine and science in sports and exercise, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Effect of histamine-receptor antagonism on leg blood flow during exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Matthew R ElyDepartment of Human Physiology, University of Oregon, Eugene, OR.
Dylan C SieckDepartment of Human Physiology, University of Oregon, Eugene, OR.
Joshua E MangumDepartment of Human Physiology, University of Oregon, Eugene, OR.
Emily A LarsonDepartment of Human Physiology, University of Oregon, Eugene, OR.
Leandro C BritoSchool of Physical Education and Sport, University of São Paulo, São Paulo, BRAZIL.
Christopher T MinsonDepartment of Human Physiology, University of Oregon, Eugene, OR.
John R HalliwillDepartment of Human Physiology, University of Oregon, Eugene, OR.
University of Oregon · USUniversidade de São Paulo · BR

Funding

Exercise, Histamine Receptors, & Vascular Health In AgingR01HL115027 · NHLBI · UNIVERSITY OF OREGON · PI HALLIWILL, JOHN R. · 2013 to 2016
$1.8M
NHLBI NIH HHS R01 HL115027
6 · The paper itself

Abstract

Histamine is released within skeletal muscle during exercise. In humans, antihistamines have no effect on speed, power output, or time-to-completion of short-duration high-intensity exercise. In mice, blocking histamine's actions decreases speed and duration of endurance tasks. It is unknown if these opposing outcomes are the result of differences in histamine's actions between species or are related to duration and/or intensity of exercise, as blocking histamine during endurance exercise has not been examined in humans. PURPOSE: Determine the effects of histamine-receptor antagonism on cycling time trial performance in humans, with and without a preceding bout of sustained steady-state exercise.

methodsEleven (3F) competitive cyclists performed six 10-km time trials on separate days. The first two time trials served as familiarization. The next four time trials were performed in randomized-block order, where two were preceded by 120 min of seated rest (rest) and two by 120 min of cycling exercise (Exercise) at 50% V˙O2peak. Within each block, subjects consumed either combined histamine H1 and H2 receptor antagonists (Blockade) or Placebo, before the start of the 120-min Rest/Exercise.

resultsBlockade had no discernible effects on hemodynamic or metabolic variables during Rest or Exercise. However, Blockade increased time-to-completion of the 10-km time trial compared with Placebo (+10.5 ± 3.7 s, P < 0.05). Slowing from placebo to blockade was not different between rest (+8.7 ± 5.2 s) and Exercise (+12.3 ± 5.8 s, P = 0.716).

conclusionsExercise-related histaminergic signaling appears inherent to endurance exercise and may play a role in facilitating optimal function during high-intensity endurance exercise.

Indexed as

BicyclingBlood GlucoseCompetitive BehaviorDouble-Blind MethodExercise TestFemaleHemodynamicsHistamineHistamine H1 AntagonistsHistamine H2 AntagonistsHumansKneeLactic AcidMaleMuscle, SkeletalMuscle StrengthBlood GlucoseHistamineHistamine H1 AntagonistsHistamine H2 AntagonistsLactic Acid

Identifiers

PMID30694974
PMCPMC6579648
OpenAlexW2913288990

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.